Magnetic Resonance Imaging of Brain Involvement in Dogs Using Paramagnetic Contrast Enhancement with Mn(II)-DCTA P

• Published in: Bulletin of experimental biology and medicine 2016-09, Vol.161 (5), p.715-718
• Main Authors: Ussov, W. Yu, Belyanin, M. L., Bezlepkin, A. I., Borodin, O. Yu, Bobrikova, E. E., Shimanovskii, N. L.
• Format: Article
• Language: English
• Subjects: Animals; Babesia canis; Babesiosis - diagnostic imaging; Biomedical and Life Sciences; Biomedicine; Brain; Brain - diagnostic imaging; Cell Biology; Contrast media; Contrast Media - pharmacokinetics; Cyclohexane; Cytokinins; Dog Diseases - diagnostic imaging; Dogs; Drug Evaluation, Preclinical; Edetic Acid - analogs & derivatives; Edetic Acid - pharmacokinetics; Experimental Methods for Clinical Practice; Health aspects; Injuries; Internal Medicine; Laboratory Medicine; Magnetic Resonance Imaging; Pathology
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-016-3492-1

Experimental study of a new paramagnetic complex Mn-DCTA is carried out. The complex (0.5 M manganese(II) solution with trans-1,2-diamine cyclohexane-N,N,N’,N’-tetraacetic acid; Cyclomang) was used for contrast magnetic resonance imaging visualization of CNS involvement in dogs with severe forms of Babesia canis infection. CNS injuries were visualized in all cases, with highly intense contrasting at the expense of Mn-DCTA accumulation at the periphery of the damaged zone. Quantitative evaluation of the paramagnetic accumulation in the focus showed that the amplification index wa s 1.19±0.11 for the central areas and 1.47±0.17 for the peripheral ones. The pituitary (1.18±0.05) and vascular plexuses of the lateral ventricles (1.12±0.09) were also contrasted. Injection of the paramagnetic to dogs was not associated with any kinds of pathological or physiological reactions. Mn-DCTA complex allowed contrast visualization of the focal injuries to the CNS and could be regarded as a paramagnetic contrast agent for magnetic resonance imaging of brain injuries in dogs.