Abdominal Obesity and Brain Atrophy in Type 2 Diabetes Mellitus: e0142589

Aim Type 2 diabetes mellitus (T2D) is associated with gray matter atrophy. Adiposity and physical inactivity are risk factors for T2D and brain atrophy. We studied whether the associations of T2D with total gray matter volume (GMV) and hippocampal volume (HV) are dependent on obesity and physical ac...

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Published in:PloS one 2015-11, Vol.10 (11)
Main Authors: Climie, Rachel ED, Moran, Chris, Callisaya, Michele, Blizzard, Leigh, Sharman, James E, Venn, Alison, Phan, Thanh G, Beare, Richard, bes, Josephine, Blackburn, Nicholas B
Format: Article
Language:English
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Summary:Aim Type 2 diabetes mellitus (T2D) is associated with gray matter atrophy. Adiposity and physical inactivity are risk factors for T2D and brain atrophy. We studied whether the associations of T2D with total gray matter volume (GMV) and hippocampal volume (HV) are dependent on obesity and physical activity. Materials and Methods In this cross-sectional study, we measured waist-hip ratio (WHR), body mass index (BMI), mean steps/day and brain volumes in a community dwelling cohort of people with and without T2D. Using multivariable linear regression, we examined whether WHR, BMI and physical activity mediated or modified the association between T2D, GMV and HV. Results There were 258 participants with (mean age 67 plus or minus 7 years) and 302 without (mean age 72 plus or minus 7 years) T2D. Adjusting for age, sex and intracranial volume, T2D was independently associated with lower total GMV (p = 0.001) and HV (p
ISSN:1932-6203
DOI:10.1371/journal.pone.0142589