Adhesion of Blood Clots Can Be Enhanced When Copolymerized with a Macromer That Is Crosslinked by Coagulation Factor XIIIa

The adhesion of blood clots to blood vessels, such as through the adhesion of fibrin, is essential in hemostasis. While numerous strategies for initiating clot formation and preventing clot lysis are being developed to create improved hemostatic agents, strategies for enhancing clot adhesion have no...

Full description

Saved in:
Bibliographic Details
Published in:Biomacromolecules 2016-06, Vol.17 (6), p.2248-2252
Main Authors: Chan, Karen Y. T, Zhao, Chunyi, Siren, Erika M. J, Chan, Jeanne C. Y, Boschman, Jeffrey, Kastrup, Christian J
Format: Article
Language:English
Subjects:
Animals
Blood Coagulation - drug effects
Cross-Linking Reagents - pharmacology
Factor XIIIa - metabolism
Fibrinogens, Abnormal - physiology
Humans
Mice
Mice, Inbred C57BL
Mice, Knockout
Plasma - drug effects
Plasma - metabolism
Polymers - pharmacology
Thrombosis - drug therapy
Thrombosis - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The adhesion of blood clots to blood vessels, such as through the adhesion of fibrin, is essential in hemostasis. While numerous strategies for initiating clot formation and preventing clot lysis are being developed to create improved hemostatic agents, strategies for enhancing clot adhesion have not been widely explored. Here, we show that adhesion of blood clots can be increased by adding a previously characterized synthetic polymer that is crosslinked by coagulation factor XIIIa during clotting. Addition of the polymer to normal plasma increased the adhesive strength of clots by 2-fold. It also recovered the adhesive strength of nonadhesive fibrinogen-deficient whole blood clots from
ISSN:1525-7797
1526-4602
DOI:10.1021/acs.biomac.6b00481