Successful treatment of inverted Takotsubo cardiomyopathy after severe traumatic brain injury with milrinone after dobutamine failure

• Published in: Heart & lung 2016-09, Vol.45 (5), p.406-408
• Main Authors: Mrozek, Ségolène, MD, Srairi, Mohamed, MD, Marhar, Fouad, MD, Delmas, Clément, MD, Gaussiat, François, MD, Abaziou, Timothée, MD, Larcher, Claire, MD, Atthar, Vincent, MD, Menut, Rémi, MD, Fourcade, Olivier, MD, PhD, Geeraerts, Thomas, MD, PhD
• Format: Article
• Language: English
• Subjects: Adolescent; Brain Injuries, Traumatic - complications; Brain Injuries, Traumatic - diagnosis; Cardiomyopathy; Cardiotonic Agents - administration & dosage; Cardiovascular; Catecholamines; Critical Care; Dobutamine; Dobutamine - therapeutic use; Female; Heart failure; Hemodynamics - drug effects; Humans; Medical treatment; Milrinone; Milrinone - administration & dosage; Prescription drugs; Pulmonary/Respiratory; Takotsubo cardiomyopathy; Takotsubo Cardiomyopathy - etiology; Takotsubo Cardiomyopathy - physiopathology; Takotsubo Cardiomyopathy - therapy; Trauma Severity Indices; Traumatic brain injury; Treatment Failure
• ISSN: 0147-9563; 1527-3288
• DOI: 10.1016/j.hrtlng.2016.06.007

Abstract Background Takotsubo cardiomyopathy can occur at the early phase of severe acute brain injuries. In the case of cardiac output decrease or shock, the optimal treatment is still a matter of debate. Due to massive stress hormone release, the infusion of catecholamines may have limited effects and may even aggravate cardiac failure. Other inotropic agents may be an option. Levosimendan has been shown to have potential beneficial effects in this setting, although milrinone has not been studied. Methods We report a case of a young female presenting with inverted Takotsubo cardiomyopathy syndrome after severe traumatic brain injury. Results Due to hemodynamic instability and increasing levels of infused norepinephrine, dobutamine infusion was begun but rapidly stopped due to tachyarrhythmia. Milrinone infusion stabilized the patient's hemodynamic status and improved cardiac output without deleterious effects. Conclusion Milrinone could be a good alternative when inotropes are required in Takotsubo cardiomyopathy and when dobutamine infusion is associated with tachyarrhythmia.