Water soluble extracts from Actinidia arguta, PG102, attenuates house dust mite-induced murine atopic dermatitis by inhibiting the mTOR pathway with Treg generation

Actinidia arguta is widespread in northeastern Asia, being found in Siberia, Korea, Japan, and northern China. These fruits have been documented to regulate the uncontrolled heat of body resulting in various allergic diseases in the Korean traditional medicine. PG102, a water-soluble extract from an...

Full description

Saved in:
Bibliographic Details
Published in:Journal of ethnopharmacology 2016-12, Vol.193, p.96-106
Main Authors: Bae, Min-Jung, Lim, Seonung, Lee, Doo Suk, Ko, Kyoung Ryang, Lee, Wonwoo, Kim, Sunyoung
Format: Article
Language:English
Subjects:
Actinidia - chemistry
Actinidia arguta
Animals
Atopic dermatittis
Dermatitis, Atopic - drug therapy
Dermatitis, Atopic - immunology
Foxp3
Mice
MTOR
PG102
Plant Extracts - pharmacology
Pyroglyphidae - immunology
Signal Transduction - drug effects
Signal Transduction - immunology
STAT5
T-Lymphocytes, Regulatory - drug effects
T-Lymphocytes, Regulatory - immunology
TOR Serine-Threonine Kinases - immunology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Actinidia arguta is widespread in northeastern Asia, being found in Siberia, Korea, Japan, and northern China. These fruits have been documented to regulate the uncontrolled heat of body resulting in various allergic diseases in the Korean traditional medicine. PG102, a water-soluble extract from an edible fruit, A. arguta, has been previously shown to control various factors involved in allergic pathogenesis. In this study, we investigated whether PG102 prevents chronic allergic reactions via the generation of Tregs, which play a preventive role in the pathogenesis of allergic disease. In dust mite extract-induced chronic atopic dermatitis, orally administered PG102 inhibited symptoms of dermatitis, including ear swelling and erythema, and decreased lymphocyte infiltration into the inflamed region. Moreover, PG102 reduced inflammatory T cell responses and increased the expression levels of Foxp3 and other Treg-related genes. PG102 treatment enhanced the induction of CD4+Foxp3+ Tregs from naive CD4+CD62L+ T cells, probably via the inhibition of mTOR activation and the phosphorylation of STAT5 rather than using the TGF-β signaling pathway. PG102 may have potential as an orally active immunosuppressor for preventing chronic inflammatory diseases. [Display omitted]
ISSN:0378-8741
1872-7573
DOI:10.1016/j.jep.2016.08.004