The evolution, structure and function of the ray finned fish (Actinopterygii) glucocorticoid receptors

Highlights • The majority of teleost fish possess 2 glucocorticoid receptors termed GR1 and GR2. • GR1 possess a 9 amino acids (aa) inserts between the zinc fingers of the DNA binding domain. • The 9 aas are absent in teleost GR2, as well as tetrapod and Chondrichtyes GRs. • The 9 aa insert is uniqu...

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Bibliographic Details
Published in:General and comparative endocrinology 2017-09, Vol.251, p.4-11
Main Author: Bury, Nic R
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Endocrinology & Metabolism
Evolution
Evolution, Molecular
Fish
Fishes - genetics
Genome
Glucocorticoid receptors
Phylogeny
Receptors, Glucocorticoid - chemistry
Receptors, Glucocorticoid - genetics
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Summary:Highlights • The majority of teleost fish possess 2 glucocorticoid receptors termed GR1 and GR2. • GR1 possess a 9 amino acids (aa) inserts between the zinc fingers of the DNA binding domain. • The 9 aas are absent in teleost GR2, as well as tetrapod and Chondrichtyes GRs. • The 9 aa insert is unique to the Actinopterygii being also present in basal ray-finned fish.
ISSN:0016-6480
1095-6840
DOI:10.1016/j.ygcen.2016.06.030