Serum Sortilin-derived Propeptides Concentrations are decreased in Major Depressive Disorder Patients

Abstract Background Despite intense research on mechanisms underlying the depressive pathophysiology, reliable biomarkers to assess antidepressant treatment response are still lacking. Since the sortilin-derived propeptide (PE) displays potent antidepressant activities and can be measured in the blo...

Full description

Saved in:
Bibliographic Details
Published in:Journal of affective disorders 2017-01, Vol.208, p.443-447
Main Authors: Devader, Christelle, Roulot, Morgane, Moréno, Sébastien, Minelli, Alessandra, Bortolomasi, Marco, Congiu, Chiara, Gennarelli, Massimo, Borsotto, Marc, Heurteaux, Catherine, Mazella, Jean
Format: Article
Language:English
Subjects:
Adaptor Proteins, Vesicular Transport - blood
Adult
Amino Acid Sequence
Animals
Biomarker
Biomarkers - blood
Cohort Studies
Depression
Depressive Disorder, Major - blood
Diagnosis
Diagnostic and Statistical Manual of Mental Disorders
Female
Humans
Male
Mice
Mice, Inbred C57BL
Middle Aged
Propeptide
Psychiatry
Sortilin
Swimming - psychology
TREK-1
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Background Despite intense research on mechanisms underlying the depressive pathophysiology, reliable biomarkers to assess antidepressant treatment response are still lacking. Since the sortilin-derived propeptide (PE) displays potent antidepressant activities and can be measured in the blood of rodents, we wondered whether in human its seric level can vary between patients affected by major depressive disorder (MDD) and healthy controls and after antidepressant treatment. Methods By using a specific dosing method, characterized by structure-recognition analysis with various synthesized PE analogues, we conducted a translational study to test whether blood levels of PE are under pathophysiological regulation and could serve as biomarkers of the depression state. Results The serum concentration of PE, a peptide displaying potent antidepressant activities in rodents, is decreased in patients affected by major depressive disorder (MDD) when compared to healthy non-psychiatric controls cohort (p = 0.035). Interestingly, pharmacological antidepressant treatments restore normal PE levels. Limitations The limitation of the study concerns the relatively small patient samples that could negatively affect the likelihood that a nominally statistically significant finding actually reflects a true effect. Conclusions The longitudinal quantification of the serum PE concentration could assist psychiatrists in the diagnosis of antidepressant response efficacy, and the need to modify the therapeutic strategy.
ISSN:0165-0327
1573-2517
DOI:10.1016/j.jad.2016.10.049