Lack of association between LRRK2 G2385R and cognitive dysfunction in Korean patients with Parkinson’s disease

Highlights • Longer PD duration, older age-at-study entry and presence of depression were associated with cognitive dysfunction in PD. • Heterozygous carrier of G2385R of LRRK2 was found in 7.7% of Parkinson’s disease (PD) patients. • There was no association between LRRK2 G2385R genotype and cognit...

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Published in:Journal of clinical neuroscience 2017-02, Vol.36, p.108-113
Main Authors: Hong, Jeong Hoon, Kim, Yue Kyung, Park, Jae Seol, Lee, Ji Eun, Oh, Mi Sun, Chung, Eun Joo, Kim, Jeong-Yeon, Sung, Young-Hee, Lyoo, Chul Hyoung, Lee, Jae Hyeok, Kwon, Do-Young, Kim, Hyun Sook, Shin, Hae-Won, Park, Sun Ah, Park, In-Seok, Kim, Joong-Seok, Lee, Phil Hyu, Koh, Seong-Beom, Baik, Jong Sam, Kim, Sang Jin, Ma, Hyeo-Il, Kim, Jae Woo, Kim, Yun Joong
Format: Article
Language:English
Subjects:
Aged
Case-Control Studies
Cognitive Dysfunction - complications
Cognitive Dysfunction - genetics
Cognitive impairment
Female
Genetic risk factor
Humans
Idiopathic Parkinson’s disease
Leucine-rich repeat kinase 2
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 - genetics
Male
Middle Aged
Neurology
Parkinson Disease - complications
Parkinson Disease - genetics
Polymorphism
Polymorphism, Single Nucleotide
Republic of Korea
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Summary:Highlights • Longer PD duration, older age-at-study entry and presence of depression were associated with cognitive dysfunction in PD. • Heterozygous carrier of G2385R of LRRK2 was found in 7.7% of Parkinson’s disease (PD) patients. • There was no association between LRRK2 G2385R genotype and cognitive dysfunction assessed by MMSE Z score or MoCA in PD. • The interaction terms between PD duration and the LRRK2 G2385R genotype were not significant for the MMSE Z score. • There was an interaction between PD duration and LRRK2 G2385R genotype for cognitive decline assessed by MoCA score in PD.
ISSN:0967-5868
1532-2653
DOI:10.1016/j.jocn.2016.10.013