Serotonin Syndrome: Prophylactic Treatment With Cyproheptadine

Despite the numerous advantages of linezolid therapy, one disadvantage continuing to hinder its use is the risk of serotonin syndrome when coadministered with other serotonergic agents. Developing a better understanding of serotonin syndrome is essential for the prevention and management of this pot...

Full description

Saved in:
Bibliographic Details
Published in:Primary care companion for CNS disorders 2016-08, Vol.18 (4)
Main Authors: Deardorff, O Greg, Khan, Talha, Kulkarni, Gaurav, Doisy, Richard, Loehr, Colleen
Format: Article
Language:English
Subjects:
Adult
Anti-Bacterial Agents - adverse effects
Cyproheptadine - therapeutic use
Drug Interactions
Humans
Linezolid - adverse effects
Male
Osteomyelitis - drug therapy
Serotonin Antagonists - therapeutic use
Serotonin Syndrome - prevention & control
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Despite the numerous advantages of linezolid therapy, one disadvantage continuing to hinder its use is the risk of serotonin syndrome when coadministered with other serotonergic agents. Developing a better understanding of serotonin syndrome is essential for the prevention and management of this potentially life-threatening condition. This report describes a patient with schizophrenia, depression, and severe, acute osteomyelitis. The patient was taking multiple serotonergic agents and required the use of linezolid without the possibility of a sufficient washout period. The severity of the patient's condition in conjunction with increased risk for serotonin syndrome warranted prophylactic treatment with cyproheptadine. The complex pathophysiology of prophylactic treatment of serotonin syndrome with cyproheptadine is worthy of discussion.
ISSN:2155-7780
DOI:10.4088/PCC.16br01966