Sex-dependent differences in the in vivo respiratory phenotype of the TASK-1 potassium channel knockout mouse

• Published in: Respiratory physiology & neurobiology 2017-11, Vol.245, p.13-28
• Main Authors: Jungbauer, Stefan, Buehler, Philipp Karl, Neubauer, Jacqueline, Haas, Cordula, Heitzmann, Dirk, Tegtmeier, Ines, Sterner, Christina, Barhanin, Jacques, Georgieff, Michael, Warth, Richard, Thomas, Jörg
• Format: Article
• Language: English
• Subjects: Aging - metabolism; Anesthetics, Inhalation - pharmacology; Animals; Animals, Newborn; Chemoreception; Cohort Studies; Female; Humans; Hypercapnia - physiopathology; Infant; Isoflurane - pharmacology; Male; Medical Education; Mice, Inbred C57BL; Mice, Knockout; Neonatal mice; Nerve Tissue Proteins - deficiency; Nerve Tissue Proteins - genetics; Plethysmography, Whole Body; Potassium Channels, Tandem Pore Domain - deficiency; Potassium Channels, Tandem Pore Domain - genetics; Pulmonary/Respiratory; Respiration - drug effects; Sex Characteristics; Sex-dependent; Sudden Infant Death - genetics; TASK-1 channel; Tidal Volume - physiology; Whole body plethysmograph
• ISSN: 1569-9048; 1878-1519
• DOI: 10.1016/j.resp.2016.11.005

Highlights • Under different respiratory stimuli respiration in adult female TASK-1−/− mice was unaffected, whereas adult male TASK-1−/− mice showed a modified breathing pattern under control and hypoxia conditions. • Adult TASK-1−/− mice of both sexes showed a normal hypercapnia response. • Neonatal TASK-1−/− mice showed 30–40% diminished ventilation under control conditions and increased susceptibility for apnea under hypoxia. • Screening for mutations in the human TASK-1 gene (KCNK3) in 155 cases of sudden infant death syndrome (SIDS) was inconclusive speaking against a prominent role of TASK-1 mutations in SIDS.