Doppler screening and predictors of adverse outcomes in high risk pregnancies affected by tobacco

•Tobacco not associated independently with elevated Doppler measurements, or adverse outcome.•Doppler artery indices identified significant associations: IUGR, preeclampsia, low birth weight, pre-term birth and composite adverse outcome variable.•Umbilical and uterine left systolic/diastolic velocit...

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Bibliographic Details
Published in:Reproductive toxicology (Elmsford, N.Y.) N.Y.), 2017-01, Vol.67, p.10-14
Main Authors: Stalzer, Alison, Seybold, Dara, Hossino, Deena, Broce, Mike, Calhoun, Byron
Format: Article
Language:English
Subjects:
Birth outcome
Doppler
Female
Humans
Predictive Value of Tests
Pregnancy
Pregnancy Complications - diagnostic imaging
Pregnancy Complications - etiology
Pregnancy Outcome
Pregnancy, High-Risk
Retrospective Studies
Screening
Smoking - adverse effects
Tobacco
Ultrasonography, Doppler
Ultrasonography, Prenatal
Umbilical Arteries - diagnostic imaging
Uterine Artery - diagnostic imaging
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Summary:•Tobacco not associated independently with elevated Doppler measurements, or adverse outcome.•Doppler artery indices identified significant associations: IUGR, preeclampsia, low birth weight, pre-term birth and composite adverse outcome variable.•Umbilical and uterine left systolic/diastolic velocity ratios and nulliparity increased odds for adverse outcome. The purpose of this study was to investigate associations between Doppler measurements and adverse outcomes in an obstetric population with high tobacco use. This retrospective study included patients with Doppler data (umbilical systolic/diastolic velocity ratios (S/D), uterine S/D, uterine left/right ratio index (RI)). Receiver operator characteristic curve analysis determined cut-off elevated Doppler indices. Stepwise logistic regression was used to predict adverse outcomes. 338 of 745 patients (45.4%) had adverse outcomes. Doppler artery indices identified significant associations with IUGR, preeclampsia, low birth weight, pre-term birth and composite adverse outcome variable. An elevated Umbilical S/D was 2.1 (95% Confidence Interval (CI): 1.5–2.9; p
ISSN:0890-6238
1873-1708
DOI:10.1016/j.reprotox.2016.11.006