Repeat Cytoreductive Surgery with or Without Perioperative Intraperitoneal Chemotherapy for Peritoneal Surface Malignancy

Abstract Background A significant proportion of patients with peritoneal surface malignancy (PSM) experienced recurrence after initial cytoreductive surgery (CRS). Thus the aims of this study were to determine short-term outcomes and long-term survivals associated with repeat CRS. Methods This was a...

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Bibliographic Details
Published in:The American journal of surgery 2017-06, Vol.213 (6), p.1024-1030
Main Authors: Huang, Yeqian, BMed, MD, Alzahrani, Nayef A., MBBS, Chua, Terence C., MBBS, PhD, MRCS (Ed), Liauw, Winston, MBBS, M Med Sci, Morris, David L., MD, PhD
Format: Article
Language:English
Subjects:
5-Fluorouracil
Abdomen
Adolescent
Adult
Aged
Aged, 80 and over
Allergies
Antineoplastic Agents - therapeutic use
Bicarbonates
Cancer
Cancer therapies
Carbonates
Carcinoma - drug therapy
Carcinoma - mortality
Carcinoma - surgery
Chemotherapy
Chemotherapy, Adjuvant
Cisplatin
Classification
Colorectal carcinoma
Complications
Computed tomography
Cytoreduction Surgical Procedures
Cytoreductive surgery
Death
Diagnosis
Emergencies
Emission measurements
Female
Historical account
Hospitals
Humans
Independent variables
Indicators
Intervals
Intervention
Liver
Male
Males
Malignancy
Management
Markers
Mathematical models
Medical personnel
Medical prognosis
Mesothelioma
Metastases
Middle Aged
Mitomycin
Morbidity
Mortality
Multivariate analysis
Neoplasms
Nodules
Ovarian cancer
Patients
Perioperative Care
Peritoneal Neoplasms - drug therapy
Peritoneal Neoplasms - mortality
Peritoneal Neoplasms - surgery
Peritoneal surface malignancy
Peritoneum
Positron emission tomography
Quality
Recurrence
Regression analysis
Reoperation
Repeat
Retrospective Studies
Sodium
Statistical analysis
Statistical tests
Statistics
Studies
Surgery
Surgical outcomes
Survival
Survival analysis
Survival Rate
Tomography
Tumors
Young Adult
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Summary:Abstract Background A significant proportion of patients with peritoneal surface malignancy (PSM) experienced recurrence after initial cytoreductive surgery (CRS). Thus the aims of this study were to determine short-term outcomes and long-term survivals associated with repeat CRS. Methods This was a retrospective study of prospectively collected data of consecutive patients with PSM who underwent CRS by one surgical team at St George Hospital in Sydney, Australia between Jan 1996 and May 2016. Results There was no significant difference in hospital mortality (p=0.343) and major morbidity rate (p=0.454). Patients who underwent repeat surgery had a significantly higher 5-year overall survival (OS) rate (p
ISSN:0002-9610
1879-1883
DOI:10.1016/j.amjsurg.2016.09.046