Reported outcomes of 453 pregnancies in patients with Gaucher disease: An analysis from the Gaucher outcome survey

Gaucher disease (GD) may worsen during pregnancy, leading to the discussion of continuing treatment during pregnancy. We examined fetal outcomes of pregnancies reported in the Gaucher Outcome Survey, an international GD-specific registry established in 2010. A total of 453 pregnancies were reported....

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Bibliographic Details
Published in:Blood cells, molecules, & diseases molecules, & diseases, 2018-02, Vol.68, p.226-231
Main Authors: Lau, Heather, Belmatoug, Nadia, Deegan, Patrick, Goker-Alpan, Ozlem, Schwartz, Ida Vanessa D., Shankar, Suma P, Panahloo, Zoya, Zimran, Ari
Format: Article
Language:English
Subjects:
Enzyme replacement therapy
Gaucher disease
Pregnancy
Velaglucerase alfa
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Summary:Gaucher disease (GD) may worsen during pregnancy, leading to the discussion of continuing treatment during pregnancy. We examined fetal outcomes of pregnancies reported in the Gaucher Outcome Survey, an international GD-specific registry established in 2010. A total of 453 pregnancies were reported. Most pregnancies (336/453, 74.2%) were in women who did not receive GD-specific treatment during pregnancy, while enzyme replacement therapy (ERT) was received during 117/453 (25.8%) pregnancies. No pregnancies exposed to substrate reduction therapy were reported. The percentage of normal outcomes (live birth delivered at term with no congenital abnormalities) was similar in untreated and treated pregnancies (92.9% vs. 91.4%). The percentage of spontaneous abortions in untreated pregnancies was 3.6% (95% CI, 1.9%– 6.2%) compared with 6.9% (95% CI, 3.0%–13.1%) in treated pregnancies (p=0.1866). In women who received velaglucerase alfa
ISSN:1079-9796
1096-0961
DOI:10.1016/j.bcmd.2016.10.003