Effect of exercise intensity on postprandial lipemia, markers of oxidative stress, and endothelial function after a high-fat meal

• Published in: Applied physiology, nutrition, and metabolism nutrition, and metabolism, 2016-12, Vol.41 (12), p.1278-1284
• Main Authors: Lopes Krüger, Renata, Costa Teixeira, Bruno, Boufleur Farinha, Juliano, Cauduro Oliveira Macedo, Rodrigo, Pinto Boeno, Francesco, Rech, Anderson, Lopez, Pedro, Silveira Pinto, Ronei, Reischak-Oliveira, Alvaro
• Format: Article
• Language: English
• Subjects: Biomarkers; Biomarkers - blood; Brazil - epidemiology; Cardiovascular Diseases - epidemiology; Cardiovascular Diseases - prevention & control; Care and treatment; Comparative studies; Diet, High-Fat - adverse effects; dilatation dépendante du flux sanguin; dommage oxydatif; Endothelium, Vascular - metabolism; Endothelium, Vascular - physiology; Endothelium, Vascular - physiopathology; Exercise; Exercise physiology; Exercise Test; Exercise therapy; flow-mediated dilatation; Health aspects; Hematology; Humans; Hyperlipidemias - etiology; Hyperlipidemias - metabolism; Hyperlipidemias - physiopathology; Hyperlipidemias - prevention & control; Ketogenic diet; Lipemia; Lipid Peroxidation; Male; Nitrates - blood; Nitrites - blood; nitrites/nitrates; Observations; oxidative damage; Oxidative Stress; Patient outcomes; peroxydation lipidique; Physical Exertion; Physical Fitness; Postprandial Period; postprandial responses; Risk; Running; réponses postprandiales; Thiobarbituric Acid Reactive Substances - analysis; Triglycerides - blood; Vasodilation
• ISSN: 1715-5312; 1715-5320
• DOI: 10.1139/apnm-2016-0262

The aim of this study was to compare the effects of 2 different exercise intensities on postprandial lipemia, oxidative stress markers, and endothelial function after a high-fat meal (HFM). Eleven young men completed 2-day trials in 3 conditions: rest, moderate-intensity exercise (MI-Exercise) and heavy-intensity exercise (HI-Exercise). Subjects performed an exercise bout or no exercise (Rest) on the evening of day 1. On the morning of day 2, an HFM was provided. Blood was sampled at fasting (0 h) and every hour from 1 to 5 h during the postprandial period for triacylglycerol (TAG), thiobarbituric acid reactive substance (TBARS), and nitrite/nitrate (NOx) concentrations. Flow-mediated dilatation (FMD) was also analyzed. TAG concentrations were reduced in exercise conditions compared with Rest during the postprandial period (P < 0.004). TAG incremental area under the curve (iAUC) was smaller after HI-Exercise compared with Rest (P = 0.012). TBARS concentrations were reduced in MI-Exercise compared with Rest (P < 0.041). FMD was higher in exercise conditions than Rest at 0 h (P < 0.02) and NOx concentrations were enhanced in MI-Exercise compared with Rest at 0 h (P < 0.01). These results suggest that acute exercise can reduce lipemia after an HFM. However, HI-Exercise showed to be more effective in reducing iAUC TAG, which might suggest higher protection against postprandial TAG enhancement. Conversely, MI-Exercise can be beneficial to attenuate the susceptibility of oxidative damage induced by an HFM and to increase endothelial function in the fasted state compared with Rest.