French consensus. Idiopathic hypersomnia: Investigations and follow-up

Idiopathic hypersomnia is a rare, central hypersomnia, recently identified and to date of unknown physiopathology. It is characterised by a more or less permanent, excessive daytime sleepiness, associated with long and unrefreshing naps. Night-time sleep is of good quality, excessive in quantity, as...

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Bibliographic Details
Published in:Revue neurologique 2017-01, Vol.173 (1-2), p.32-37
Main Authors: Leu-Semenescu, S., Quera-Salva, M.-A., Dauvilliers, Y.
Format: Article
Language:English
Subjects:
Aftercare - methods
Biomarker
Consensus
Continuous polysomnography
Diagnosis
Diagnosis, Differential
Diagnostic Techniques, Neurological
Excessive sleepiness
Follow-Up Studies
France - epidemiology
GABA
Humans
Hypersomnolence, Idiopathic - diagnosis
Hypersomnolence, Idiopathic - epidemiology
Hypersomnolence, Idiopathic - therapy
Idiopathic hypersomnia
Polysomnography
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Description
Summary:Idiopathic hypersomnia is a rare, central hypersomnia, recently identified and to date of unknown physiopathology. It is characterised by a more or less permanent, excessive daytime sleepiness, associated with long and unrefreshing naps. Night-time sleep is of good quality, excessive in quantity, associated with sleep inertia in the subtype previously described as “with long sleep time”. Diagnosis of idiopathic hypersomnia is complex due to the absence of a quantifiable biomarker, the heterogeneous symptoms, which overlap with the clinical picture of type 2 narcolepsy, and its variable evolution over time. Detailed evaluation enables other frequent causes of somnolence, such as depression or sleep deprivation, to be eliminated. Polysomnography and multiple sleep latency tests (MSLT) are essential to rule out other sleep pathologies and to objectify excessive daytime sleepiness. Sometimes the MSLT do not show excessive sleepiness, hence a continued sleep recording of at least 24hours is necessary to show prolonged sleep (>11h/24h). In this article, we propose recommendations for the work-up to be carried out during diagnosis and follow-up for patients suffering from idiopathic hypersomnia.
ISSN:0035-3787
DOI:10.1016/j.neurol.2016.09.015