Profile of cognitive function in adults with duchenne muscular dystrophy

Abstract Background Several studies have examined intellectual functioning of boys with duchenne muscular dystrophy (DMD). However, little is known about the remaining cognitive weaknesses in adults with DMD. Objective The purpose of this study was to investigate the profile of cognitive functioning...

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Bibliographic Details
Published in:Brain & development (Tokyo. 1979) 2017-03, Vol.39 (3), p.225-230
Main Authors: Ueda, Yukihiko, Suwazono, Shugo, Maedo, Sino, Higuchi, Itsuro
Format: Article
Language:English
Subjects:
Adult
Attention - physiology
Cognition - physiology
Cognitive function
Duchenne muscular dystrophy
Female
Humans
Intelligence - physiology
Intelligence Tests
Male
Memory - physiology
Muscular Dystrophy, Duchenne - physiopathology
Neurology
Neuropsychological profile
Sequential processing
Wechsler Scales
Young Adult
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Summary:Abstract Background Several studies have examined intellectual functioning of boys with duchenne muscular dystrophy (DMD). However, little is known about the remaining cognitive weaknesses in adults with DMD. Objective The purpose of this study was to investigate the profile of cognitive functioning that is characteristics of adults with DMD. Methods Twenty-four subscales from the Wechsler Adult Intelligence Scale III (WAIS-III), the Clinical Assessment for Attention (CAT), and the Wechsler Memory Scale Revised (WMS-R) were used to assess participants with DMD ( N = 15; mean age = 30.4 years). Results Scores for Picture Completion, Arithmetic, Matrix Reasoning, Symbol Search, Letter-Number Sequencing, and Digit Span of the WAIS-III; all CAT scores, and Logical Memory and Delayed Logical Memory from the WMS-R were significantly deficient in adults with DMD in comparison to the normal population. Conclusion The ability to sequentially process auditory and visual information remains impaired in adults with DMD.
ISSN:0387-7604
1872-7131
DOI:10.1016/j.braindev.2016.10.005