Cold-inducible RNA binding protein in mouse mammary gland development

Highlights • CIRP decreases proliferation in the mammary gland at the lactational switch. • CIRP does not appear to have a role in the early stages of mammary gland involution. • CIRP does not affect mammary gland morphology. • CIRP may have a role in decreasing proliferation when its no longer need...

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Bibliographic Details
Published in:Tissue & cell 2016-12, Vol.48 (6), p.577-587
Main Authors: Lujan, Daniel A, Garcia, Selina, Vanderhoof, Jennifer, Sifuentes, Joshua, Brandt, Yekaterina, Wu, Yuehan, Guo, Xun, Mitchell, Therese, Howard, Tamara, Hathaway, Helen J, Hartley, Rebecca S
Format: Article
Language:English
Subjects:
A18 hnRNP
Advanced Basic Science
Animals
Apoptosis
Apoptosis - genetics
Binding sites
Breast cancer
Cancer
Cell proliferation
Cell Proliferation - genetics
CIRP
Control stability
Cytology
Epithelium
Female
Gene expression
Gene Expression Regulation, Developmental
Humans
Immunohistochemistry
Ki-67 Antigen - biosynthesis
Lactation
Lactation - genetics
Mammary gland
Mammary gland development
Mammary glands
Mammary Glands, Animal - growth & development
Mammary Glands, Animal - metabolism
Mice
Mice, Transgenic
MMTV-LTR
Morphology
mRNA stability
Pregnancy
Proteins
Puberty
Ribonucleic acid
RNA
RNA binding protein
RNA-Binding Proteins - biosynthesis
RNA-Binding Proteins - genetics
Transgenic animals
Transgenic mice
Transgenic mouse
Tumor cell lines
Weaning
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Summary:Highlights • CIRP decreases proliferation in the mammary gland at the lactational switch. • CIRP does not appear to have a role in the early stages of mammary gland involution. • CIRP does not affect mammary gland morphology. • CIRP may have a role in decreasing proliferation when its no longer needed.
ISSN:0040-8166
1532-3072
DOI:10.1016/j.tice.2016.10.004