Left atrial volume and function in dogs with naturally occurring myxomatous mitral valve disease

Myxomatous mitral valve disease (MMVD) induces progressive left atrial (LA) enlargement. The LA modulates left ventricular filling and performance through its reservoir, conduit, and contractile function. Assessment of LA size and function may provide valuable information on the level of cardiac com...

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Bibliographic Details
Published in:Journal of veterinary cardiology 2017-02, Vol.19 (1), p.24-34
Main Authors: Höllmer, M., Willesen, J.L., Tolver, A., Koch, J.
Format: Article
Language:English
Subjects:
Active left atrial emptying fraction
Animals
Atrial Function, Left
Biplane area-length method
Cardiac Volume
Congestive heart failure
Dogs
Echocardiography - veterinary
Female
Heart Valve Diseases - physiopathology
Heart Valve Diseases - veterinary
Hypertrophy, Left Ventricular - veterinary
Left atrial size
Male
Mitral Valve
Prospective Studies
Volumetric function
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Summary:Myxomatous mitral valve disease (MMVD) induces progressive left atrial (LA) enlargement. The LA modulates left ventricular filling and performance through its reservoir, conduit, and contractile function. Assessment of LA size and function may provide valuable information on the level of cardiac compensation. Left atrial function in dogs with naturally occurring MMVD remains largely unexplored. The objective of this study was to evaluate LA volume and function in dogs with naturally occurring MMVD. This prospective study included 205 client-owned dogs of different breeds, 114 healthy dogs, and 91 dogs with MMVD of different disease severities. Using two-dimensional echocardiography, the biplane area-length method was applied to assess LA volume and calculate volumetric indices of LA reservoir, conduit, and contractile function. Left atrial volume and LA stroke volume increased, whereas LA reservoir and contractile function decreased with increasing disease severity. A maximal LA volume
ISSN:1760-2734
1875-0834
DOI:10.1016/j.jvc.2016.08.006