Hippocampal atrophy on MRI is predictive of histopathological patterns and surgical prognosis in mesial temporal lobe epilepsy with hippocampal sclerosis

Highlights • Hippocampal volumes are predictive of hippocampal sclerosis patterns;. • Hippocampi are smaller in types 1 and 2, intermediate in 3 and higher in no-HS;. • Neuronal densities of CA1, CA3 and CA4 subfields influence hippocampal volume;. • CA2 subfield neuronal density does not correlate...

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Bibliographic Details
Published in:Epilepsy research 2016-12, Vol.128, p.169-175
Main Authors: Jardim, Anaclara Prada, Corso, Jeana Torres, Fernandes Castilho Garcia, Maria Teresa, Gaça, Larissa Botelho, Comper, Sandra Mara, Penteado Lancellotti, Carmen Lúcia, Centeno, Ricardo Silva, Carrete, Henrique, Cavalheiro, Esper Abrão, Scorza, Carla Alessandra, Targas Yacubian, Elza Márcia
Format: Article
Language:English
Subjects:
Adolescent
Adult
Analysis of Variance
Antigens, Nuclear - metabolism
Atrophy
Cell Count
Drug Resistant Epilepsy - diagnostic imaging
Drug Resistant Epilepsy - metabolism
Drug Resistant Epilepsy - pathology
Drug Resistant Epilepsy - surgery
Epilepsy, Temporal Lobe - diagnostic imaging
Epilepsy, Temporal Lobe - metabolism
Epilepsy, Temporal Lobe - pathology
Epilepsy, Temporal Lobe - surgery
Female
Follow-Up Studies
FreeSurfer analysis
Hippocampal atrophy
Hippocampal sclerosis
Hippocampus - diagnostic imaging
Hippocampus - metabolism
Hippocampus - pathology
Hippocampus - surgery
Humans
Immunohistochemistry
Magnetic Resonance Imaging
Male
Mesial temporal lobe epilepsy
Middle Aged
Nerve Tissue Proteins - metabolism
Neurology
Organ Size
Prognosis
Sclerosis - diagnostic imaging
Sclerosis - metabolism
Sclerosis - pathology
Sclerosis - surgery
Surgical outcome
Treatment Outcome
Young Adult
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Summary:Highlights • Hippocampal volumes are predictive of hippocampal sclerosis patterns;. • Hippocampi are smaller in types 1 and 2, intermediate in 3 and higher in no-HS;. • Neuronal densities of CA1, CA3 and CA4 subfields influence hippocampal volume;. • CA2 subfield neuronal density does not correlate with hippocampal imaging volume;. • Surgical prognosis is better in type 1 HS, intermediate in 2-3 and worse in no-HS.
ISSN:0920-1211
1872-6844
DOI:10.1016/j.eplepsyres.2016.10.014