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Hippocampal atrophy on MRI is predictive of histopathological patterns and surgical prognosis in mesial temporal lobe epilepsy with hippocampal sclerosis
Highlights • Hippocampal volumes are predictive of hippocampal sclerosis patterns;. • Hippocampi are smaller in types 1 and 2, intermediate in 3 and higher in no-HS;. • Neuronal densities of CA1, CA3 and CA4 subfields influence hippocampal volume;. • CA2 subfield neuronal density does not correlate...
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| Published in: | Epilepsy research 2016-12, Vol.128, p.169-175 |
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| Main Authors: | , , , , , , , , , , |
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| cited_by | cdi_FETCH-LOGICAL-c429t-4cb78c3279c2be598b55da2cdb401127861670bd78e1c864c221a24304124b253 |
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| cites | cdi_FETCH-LOGICAL-c429t-4cb78c3279c2be598b55da2cdb401127861670bd78e1c864c221a24304124b253 |
| container_end_page | 175 |
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| container_start_page | 169 |
| container_title | Epilepsy research |
| container_volume | 128 |
| creator | Jardim, Anaclara Prada Corso, Jeana Torres Fernandes Castilho Garcia, Maria Teresa Gaça, Larissa Botelho Comper, Sandra Mara Penteado Lancellotti, Carmen Lúcia Centeno, Ricardo Silva Carrete, Henrique Cavalheiro, Esper Abrão Scorza, Carla Alessandra Targas Yacubian, Elza Márcia |
| description | Highlights • Hippocampal volumes are predictive of hippocampal sclerosis patterns;. • Hippocampi are smaller in types 1 and 2, intermediate in 3 and higher in no-HS;. • Neuronal densities of CA1, CA3 and CA4 subfields influence hippocampal volume;. • CA2 subfield neuronal density does not correlate with hippocampal imaging volume;. • Surgical prognosis is better in type 1 HS, intermediate in 2-3 and worse in no-HS. |
| doi_str_mv | 10.1016/j.eplepsyres.2016.10.014 |
| format | article |
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metabolism</subject><subject>Neurology</subject><subject>Organ Size</subject><subject>Prognosis</subject><subject>Sclerosis - diagnostic imaging</subject><subject>Sclerosis - metabolism</subject><subject>Sclerosis - pathology</subject><subject>Sclerosis - surgery</subject><subject>Surgical outcome</subject><subject>Treatment Outcome</subject><subject>Young Adult</subject><issn>0920-1211</issn><issn>1872-6844</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqNUsFu1DAQtRAVXRZ-AfnIJYs9cRLnggQV0EpFSG05W44z2_WSxMZ2ivZT-FscdqESJ062n-fNvJk3hFDONpzx-s1-g35AHw8B4wYykuEN4-IJWXHZQFFLIZ6SFWuBFRw4PyfPY9wzxhomxDNyDo0UADWsyM9L670zevR6oDoF53cH6ib6-eaK2kh9wN6aZB-Qui3d2Zic12nnBndvTWbkR8IwRaqnnsY5nNDg7icXM99OdMRoM5Zw9C7ky-A6pOjtb_30h027nPdRQzQDhoX7gpxt9RDx5elck68fP9xdXBbXXz5dXby7LoyANhXCdI00JTStgQ6rVnZV1WswfScY57nRmtcN6_pGIjeyFgaAaxAlExxEB1W5Jq-PebPq7zPGpEYbDQ6DntDNUXFZtk0pZOasiTyGmqwwBtwqH-yow0FxphZj1F49GqMWY5afbEymvjpVmbsR-7_EP07kgPfHAMy9PlgMKhqLk8nzD2iS6p39nypv_0liBjstnnzDA8a9m8OUZ6m4iqCYul0WZNkPXpcMKoDyF_xTvNU</recordid><startdate>20161201</startdate><enddate>20161201</enddate><creator>Jardim, Anaclara Prada</creator><creator>Corso, Jeana Torres</creator><creator>Fernandes Castilho Garcia, Maria Teresa</creator><creator>Gaça, Larissa Botelho</creator><creator>Comper, Sandra Mara</creator><creator>Penteado Lancellotti, Carmen Lúcia</creator><creator>Centeno, Ricardo Silva</creator><creator>Carrete, Henrique</creator><creator>Cavalheiro, Esper Abrão</creator><creator>Scorza, Carla Alessandra</creator><creator>Targas Yacubian, Elza Márcia</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20161201</creationdate><title>Hippocampal atrophy on MRI is predictive of histopathological patterns and surgical prognosis in mesial temporal lobe epilepsy with hippocampal sclerosis</title><author>Jardim, Anaclara Prada ; Corso, Jeana Torres ; Fernandes Castilho Garcia, Maria Teresa ; Gaça, Larissa Botelho ; Comper, Sandra Mara ; Penteado Lancellotti, Carmen Lúcia ; Centeno, Ricardo Silva ; Carrete, Henrique ; Cavalheiro, Esper Abrão ; Scorza, Carla Alessandra ; Targas Yacubian, Elza Márcia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c429t-4cb78c3279c2be598b55da2cdb401127861670bd78e1c864c221a24304124b253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Analysis of Variance</topic><topic>Antigens, Nuclear - 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| identifier | ISSN: 0920-1211 |
| ispartof | Epilepsy research, 2016-12, Vol.128, p.169-175 |
| issn | 0920-1211 1872-6844 |
| language | eng |
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| source | ScienceDirect Journals |
| subjects | Adolescent Adult Analysis of Variance Antigens, Nuclear - metabolism Atrophy Cell Count Drug Resistant Epilepsy - diagnostic imaging Drug Resistant Epilepsy - metabolism Drug Resistant Epilepsy - pathology Drug Resistant Epilepsy - surgery Epilepsy, Temporal Lobe - diagnostic imaging Epilepsy, Temporal Lobe - metabolism Epilepsy, Temporal Lobe - pathology Epilepsy, Temporal Lobe - surgery Female Follow-Up Studies FreeSurfer analysis Hippocampal atrophy Hippocampal sclerosis Hippocampus - diagnostic imaging Hippocampus - metabolism Hippocampus - pathology Hippocampus - surgery Humans Immunohistochemistry Magnetic Resonance Imaging Male Mesial temporal lobe epilepsy Middle Aged Nerve Tissue Proteins - metabolism Neurology Organ Size Prognosis Sclerosis - diagnostic imaging Sclerosis - metabolism Sclerosis - pathology Sclerosis - surgery Surgical outcome Treatment Outcome Young Adult |
| title | Hippocampal atrophy on MRI is predictive of histopathological patterns and surgical prognosis in mesial temporal lobe epilepsy with hippocampal sclerosis |
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