Mechanism of Corilagin interference with IL-13/STAT6 signaling pathways in hepatic alternative activation macrophages in schistosomiasis-induced liver fibrosis in mouse model

• Published in: European journal of pharmacology 2016-12, Vol.793, p.119-126
• Main Authors: Du, Peng, Ma, Qian, Zhu, Zhi-De, Li, Gang, Wang, Yao, Li, Quan-Qiang, Chen, Yun-Fei, Shang, Zhen-Zhong, Zhang, Juan, Zhao, Lei
• Format: Article
• Language: English
• Subjects: Animals; Corilagin; Disease Models, Animal; Gene Expression Regulation - drug effects; Glucosides - pharmacology; Glucosides - therapeutic use; Hydrolyzable Tannins - pharmacology; Hydrolyzable Tannins - therapeutic use; IL-13; Interleukin-13 - metabolism; Kruppel-Like Transcription Factors - metabolism; Liver - drug effects; Liver - immunology; Liver - metabolism; Liver - pathology; Liver Cirrhosis - drug therapy; Liver Cirrhosis - etiology; Liver Cirrhosis - immunology; Liver Cirrhosis - pathology; Liver fibrosis; M2 macrophage; Macrophage Activation - drug effects; Macrophages - drug effects; Macrophages - immunology; Male; Mice; Schistosomiasis; Schistosomiasis - complications; Signal Transduction - drug effects; STAT6 Transcription Factor - metabolism
• ISSN: 0014-2999; 1879-0712
• DOI: 10.1016/j.ejphar.2016.11.018

This study tried to find the mechanism of Corilagin interference with interleukin (IL)-13/signal transducer and activator of transcription (STAT) 6 signaling pathways in IL-13-activated liver alternative activation macrophages in schistosomiasis-induced liver fibrosis in Balb/c mice. As a result, IL-13 in serum and the mRNA expression of IL-13 Receptor α1, IL-4 Receptor α and downstream mediators supressor of cytokine signaling (SOCS) 1, Kruppel-like factor (KLF) 4, peroxisome proliferator-activated receptor (PPAR) δ in the liver tissue were significantly inhibited by Corilagin (P