In vitro reduction of antibacterial activity of tigecycline against multidrug-resistant Acinetobacter baumannii with host stress hormone norepinephrine

Highlight • Norepinephrine reduces in vitro activity of tigecycline against MDR A. baumannii. • Norepinephrine does not affect colistin activity against MDR A. baumannii. • Norepinephrine augments MDR A. baumannii growth and biofilm formation. • Norepinephrine augments MDR A. baumannii adhesion on a...

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Bibliographic Details
Published in:International journal of antimicrobial agents 2016-12, Vol.48 (6), p.680-689
Main Authors: Inaba, Masato, Matsuda, Naoyuki, Banno, Hirotsugu, Jin, Wanchun, Wachino, Jun-ichi, Yamada, Keiko, Kimura, Kouji, Arakawa, Yoshichika
Format: Article
Language:English
Subjects:
Acinetobacter baumannii - drug effects
Acinetobacter baumannii - physiology
AdeFGH
Adhesion
Adrenergic alpha-Agonists - metabolism
Adult
Aged
Aged, 80 and over
Anti-Bacterial Agents - pharmacology
Bacterial Adhesion
Bacterial Load
Biofilm
Biofilms - growth & development
Colistin - metabolism
Culture Media - chemistry
Drug Antagonism
Female
Gene Expression Profiling
Genes, Bacterial
Humans
Infectious Disease
Male
Microbial Viability - drug effects
Middle Aged
Minocycline - analogs & derivatives
Minocycline - pharmacology
Multidrug-resistant Acinetobacter baumannii
Norepinephrine
Norepinephrine - metabolism
Real-Time Polymerase Chain Reaction
Tigecycline resistance
Time Factors
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Summary:Highlight • Norepinephrine reduces in vitro activity of tigecycline against MDR A. baumannii. • Norepinephrine does not affect colistin activity against MDR A. baumannii. • Norepinephrine augments MDR A. baumannii growth and biofilm formation. • Norepinephrine augments MDR A. baumannii adhesion on abiotic surfaces. • Norepinephrine upregulates expression of the adeG gene in MDR A. baumannii.
ISSN:0924-8579
1872-7913
DOI:10.1016/j.ijantimicag.2016.09.022