Cancer Precision Medicine: From Cancer Screening to Drug Selection and Personalized Immunotherapy

With the accelerating progress in basic and clinical cancer research, a huge body of new discoveries and powerful technologies has allowed us to implement a ‘Cancer Precision Medicine (CPM)’ system for cancer patients. The CPM system covers a wide range of cancer management including cancer screenin...

Full description

Saved in:
Bibliographic Details
Published in:Trends in pharmacological sciences (Regular ed.) 2017-01, Vol.38 (1), p.15-24
Main Authors: Deng, Xiaolan, Nakamura, Yusuke
Format: Article
Language:English
Subjects:
Advanced Basic Science
DNA, Neoplasm - blood
Early Detection of Cancer
HLA
Humans
immunopharmacogenomics
Immunotherapy
liquid biopsy
neoantigen and shared-antigen vaccine
Neoplasm Recurrence, Local - diagnosis
Neoplasms - therapy
personalized immunotherapy
Pharmacogenetics
Precision Medicine
Proto-Oncogene Proteins p21(ras) - genetics
Receptor, Epidermal Growth Factor - antagonists & inhibitors
Sequence Analysis, DNA
TCR-engineered T cells
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:With the accelerating progress in basic and clinical cancer research, a huge body of new discoveries and powerful technologies has allowed us to implement a ‘Cancer Precision Medicine (CPM)’ system for cancer patients. The CPM system covers a wide range of cancer management including cancer screening, monitoring of relapse/recurrence, selection/prediction of effective drugs/treatments, and personalized immunotherapy. In this system individual cancer patients expect to receive personalized care: an appropriate dose of the right drug at the right time. We here aim to summarize and discuss a possible workflow for precision medicine for cancer patients by reviewing recent booming technologies and treatments that have been used or will potentially be used in the CPM system.
ISSN:0165-6147
1873-3735
DOI:10.1016/j.tips.2016.10.013