Nanofibers containing tetracycline/β-cyclodextrin: Physico-chemical characterization and antimicrobial evaluation

•Tetracycline delivery system and its inclusion compound are proposed.•Tetracycline nanofibers and its inclusion compound have similar delivery profiles.•Tetracycline inclusion compound could protect and enhance the drug absorption. This study aimed to compare two nanofiber drug delivery systems tha...

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Bibliographic Details
Published in:Carbohydrate polymers 2017-01, Vol.156, p.417-426
Main Authors: Monteiro, Ana P.F., Rocha, Cíntia M.S.L., Oliveira, Michele F., Gontijo, Sávio M.L., Agudelo, Ricardo R., Sinisterra, Rubén D., Cortés, Maria E.
Format: Article
Language:English
Subjects:
Aggregatibacter - drug effects
Anti-Infective Agents - chemistry
Anti-Infective Agents - pharmacology
Antimicrobial activity
beta-Cyclodextrins - chemistry
beta-Cyclodextrins - pharmacology
Cyclodextrin
Electrospun
Inclusion compound
Microbial Sensitivity Tests
Nanofibers
Nanofibers - chemistry
Porphyromonas - drug effects
Tetracycline
Tetracycline - chemistry
Tetracycline - pharmacology
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Summary:•Tetracycline delivery system and its inclusion compound are proposed.•Tetracycline nanofibers and its inclusion compound have similar delivery profiles.•Tetracycline inclusion compound could protect and enhance the drug absorption. This study aimed to compare two nanofiber drug delivery systems that were prepared with an electrospun process and have the potential to serve as adjuvants for the treatment of periodontal disease. The first system was composed of polycaprolactone loaded with tetracycline (TCN) and the second was composed of polycaprolactone loaded with tetracycline/β-cyclodextrin (TCN:BCD). An antimicrobial diffusion test was performed for each of these sets of nanofibers with the microorganisms, Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis, both of which contribute to periodontal disease. In vitro release profiles were also obtained, and the nanofibers were characterized by thermal analysis, x-ray powder diffraction, infrared absorption spectroscopy, and scanning electron microscopy. Profiles of the TCN and TCN:BCD nanofibers showed that drug release occurred for up to 14days. However, the TCN:BCD nanofibers appeared to better protect and enhance the biological absorption of TCN due to the formation of a TCN:BCD inclusion complex.
ISSN:0144-8617
1879-1344
DOI:10.1016/j.carbpol.2016.09.059