Toxicology of simple and complex mixtures

Humans are exposed to mixtures of chemicals, rather than to individual chemicals. From a public health point of view, it is most relevant to answer the question of whether or not the components in a mixture interact in a way that results in an increase in their overall effect compared with the sum o...

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Bibliographic Details
Published in:Trends in Pharmacological Sciences 2001-06, Vol.22 (6), p.316-322
Main Authors: Groten, John P, Feron, Victor J, Sühnel, Jürgen
Format: Article
Language:English
Subjects:
Animals
dose-response
exposure
hazard identification
Hazardous Substances - toxicity
Humans
interaction
Models, Chemical
Risk Assessment
safety evaluation
Toxicity Tests
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Summary:Humans are exposed to mixtures of chemicals, rather than to individual chemicals. From a public health point of view, it is most relevant to answer the question of whether or not the components in a mixture interact in a way that results in an increase in their overall effect compared with the sum of the effects of the individual components. In this article, options for the hazard identification and risk assessment of simple and complex chemical mixtures will be discussed. In addition, key research needed to continue the development of hazard characterization of chemical mixtures will be described. Clearly, more collaboration among toxicologists, model developers and pharmacologists will be necessary.
ISSN:0165-6147
1873-3735
DOI:10.1016/S0165-6147(00)01720-X