Serum Albumin and C-Reactive Protein/Albumin Ratio Are Useful Biomarkers of Crohn's Disease Activity

BACKGROUND Serum albumin (ALB) may be low during acute inflammation, but it is also affected by nutritional status. Therefore, we hypothesized that ALB and the C-reactive protein/ALB ratio (CRP/ALB) may be associated with disease activity in patients with Crohn's disease (CD). MATERIAL AND METH...

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Bibliographic Details
Published in:Medical science monitor 2016-11, Vol.22, p.4393-4400
Main Authors: Qin, Guangming, Tu, Jiangfeng, Liu, Lingang, Luo, Laisheng, Wu, Jiaqi, Tao, Lisha, Zhang, Chenjing, Geng, Xiaoge, Chen, Xiaojun, Ai, Xinbo, Shen, Bo, Pan, Wensheng
Format: Article
Language:English
Subjects:
Adult
Aged
Biomarkers - blood
C-Reactive Protein - metabolism
Crohn Disease - blood
Crohn Disease - diagnosis
Female
Humans
Inflammation - blood
Male
Middle Aged
Retrospective Studies
Sensitivity and Specificity
Serum Albumin - metabolism
Severity of Illness Index
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Summary:BACKGROUND Serum albumin (ALB) may be low during acute inflammation, but it is also affected by nutritional status. Therefore, we hypothesized that ALB and the C-reactive protein/ALB ratio (CRP/ALB) may be associated with disease activity in patients with Crohn's disease (CD). MATERIAL AND METHODS Altogether, 100 patients with CD and 100 age- and sex-matched healthy volunteers were retrospectively enrolled in the current study. The patients with CD were subdivided into patients with active disease (Crohn's Disease Activity Index >150) and those in remission. ALB levels, CRP levels, and lipid profiles were measured. RESULTS ALB and CRP levels and the CRP/ALB ratio were the most useful for differentiating between active and nonactive CD. ALB levels (r=-0.50, P
ISSN:1643-3750
1643-3750
DOI:10.12659/msm.897460