Are intraarticular steroids effective for knee osteoarthritis?

Knee osteoarthritis is a chronic disabling condition that is both progressive and irreversible. Intraarticular steroids are commonly used to reduce osteoarthritis symptoms and to minimize the need for surgery. Nevertheless, debate still exists regarding the efficacy and safety of steroids. To addres...

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Bibliographic Details
Published in:Medwave 2016-11, Vol.16 (Suppl5), p.e6599-e6599
Main Authors: Faúndez, Jorge, Cotoras, Petre, Irarrázaval, Sebastián
Format: Article
Language:eng ; spa
Subjects:
Glucocorticoids - administration & dosage
Glucocorticoids - adverse effects
Humans
Injections, Intra-Articular
Osteoarthritis, Knee - drug therapy
Osteoarthritis, Knee - pathology
Pain - drug therapy
Pain - etiology
Randomized Controlled Trials as Topic
Time Factors
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Summary:Knee osteoarthritis is a chronic disabling condition that is both progressive and irreversible. Intraarticular steroids are commonly used to reduce osteoarthritis symptoms and to minimize the need for surgery. Nevertheless, debate still exists regarding the efficacy and safety of steroids. To address this point, we searched Epistemonikos database which is maintained by screening 30 separate databases and identified 12 systematic reviews including 41 studies addressing steroids use in knee osteoarthritis. Of these, 40 were randomized trials. The evidence from these studies was combined using meta-analysis, and a summary of findings table was constructed following the GRADE approach. We concluded intraarticular steroid use slightly decreases short-term pain, makes little or no difference in the mid-term, and may have no effects in the long-term.
ISSN:0717-6384
0717-6384
DOI:10.5867/medwave.2016.6599