Role of Wnt5a in the Pathogenesis of Inflammatory Diseases

Wnt5a initiates pro‐inflammatory responses through activation of non‐canonical Wnt signaling pathway. Pro‐inflammatory functions of Wnt5a trigger pro‐inflammatory signaling cascades and increase secretion of pro‐inflammatory cytokines and chemokines. Wnt5a as a potent signaling molecule is strongly...

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Bibliographic Details
Published in:Journal of cellular physiology 2017-07, Vol.232 (7), p.1611-1616
Main Authors: Pashirzad, Mehran, Shafiee, Mojtaba, Rahmani, Farzad, Behnam‐Rassouli, Reihane, Hoseinkhani, Fatemeh, Ryzhikov, Mikhail, Moradi Binabaj, Maryam, Parizadeh, Mohammad Reza, Avan, Amir, Hassanian, Seyed Mahdi
Format: Article
Language:English
Subjects:
Humans
Inflammation - metabolism
Inflammation - pathology
Metabolic disorders
Models, Biological
Psoriasis
Rheumatoid arthritis
Skin diseases
Wnt Proteins - metabolism
Wnt Signaling Pathway
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Summary:Wnt5a initiates pro‐inflammatory responses through activation of non‐canonical Wnt signaling pathway. Pro‐inflammatory functions of Wnt5a trigger pro‐inflammatory signaling cascades and increase secretion of pro‐inflammatory cytokines and chemokines. Wnt5a as a potent signaling molecule is strongly implicated in a number of diseases including cancer, diabetes, metabolic disorders, and of special interest in this review, inflammatory diseases. This review summarizes the role of Wnt5a in the pathogenesis of inflammatory diseases including atherosclerosis, rheumatoid arthritis, psoriasis vulgaris and sepsis, promoting greater understanding, and clinical management of these diseases. J. Cell. Physiol. 232: 1611–1616, 2017. © 2016 Wiley Periodicals, Inc. Wnt5a as a potent signaling molecule is strongly implicated in a number of diseases including cancer, diabetes, metabolic disorders, and of special interest in this review, inflammatory diseases. This review summarizes the role of Wnt5a in the pathogenesis of inflammatory diseases including atherosclerosis, rheumatoid arthritis, psoriasis vulgaris and sepsis, promoting greater understanding and clinical management of these diseases.
ISSN:0021-9541
1097-4652
DOI:10.1002/jcp.25687