Skin lesion in a patient with acute myeloid leukemia

We present the case of a 51‐year‐old man with acute myeloid leukemia who developed fevers with a skin lesion following the first cycle of induction chemotherapy. Skin biopsy showed evidence of invasive fungal infection. Cultures remained negative, but polymerase chain reaction on tissue detected Rhi...

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Bibliographic Details
Published in:Transplant infectious disease 2017-02, Vol.19 (1), p.n/a
Main Authors: Kothari, Atul, Shalin, Sara C., Crescencio, Juan Carlos Rico, Burgess, Mary J.
Format: Article
Language:English
Subjects:
acute myeloid leukemia
Amphotericin B - administration & dosage
Amphotericin B - therapeutic use
Antibiotic Prophylaxis - adverse effects
Antifungal Agents - administration & dosage
Antifungal Agents - therapeutic use
Biopsy
Debridement
Dermatomycoses - complications
Dermatomycoses - drug therapy
Dermatomycoses - microbiology
Dermatomycoses - pathology
Febrile Neutropenia - drug therapy
Febrile Neutropenia - etiology
Febrile Neutropenia - microbiology
Forearm
Humans
Immunocompromised Host
Induction Chemotherapy - adverse effects
Induction Chemotherapy - methods
Invasive Fungal Infections - microbiology
Invasive Fungal Infections - pathology
Invasive Fungal Infections - therapy
Lesions
Leukemia
Leukemia, Myeloid, Acute - drug therapy
Male
Middle Aged
mucormycosis
Mucormycosis - complications
Mucormycosis - microbiology
Mucormycosis - pathology
Mucormycosis - therapy
Polymerase Chain Reaction
Rhizopus - isolation & purification
RNA, Fungal - isolation & purification
skin lesion
Stem cells
Triazoles - administration & dosage
Triazoles - therapeutic use
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Description
Summary:We present the case of a 51‐year‐old man with acute myeloid leukemia who developed fevers with a skin lesion following the first cycle of induction chemotherapy. Skin biopsy showed evidence of invasive fungal infection. Cultures remained negative, but polymerase chain reaction on tissue detected Rhizopus oryzae complex. The patient was started on liposomal amphotericin B and underwent surgical debridement. He was switched to posaconazole, with plans for allogeneic hematopoetic stem cell transplant in the future.
ISSN:1398-2273
1399-3062
DOI:10.1111/tid.12635