Usefulness of albumin‐bilirubin grade for evaluation of long‐term prognosis for hepatitis B‐related cirrhosis

• Published in: Journal of viral hepatitis 2017-03, Vol.24 (3), p.238-245
• Main Authors: Chen, R.‐C., Cai, Y.‐J., Wu, J.‐M., Wang, X.‐D., Song, M., Wang, Y.‐Q., Zheng, M.‐H., Chen, Y.‐P., Lin, Z., Shi, K. Q.
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Albumins - analysis; albumin‐bilirubin; Bilirubin - blood; China; cirrhosis; decision curves analysis; Decision Support Techniques; Female; Follow-Up Studies; hepatitis B; Hepatitis B, Chronic - complications; Hospitals, University; Humans; Liver Cirrhosis - diagnosis; Liver Cirrhosis - mortality; Liver Cirrhosis - pathology; Male; Middle Aged; Prognosis; ROC Curve; Survival Analysis; time‐dependent receiver operating characteristics; Young Adult
• ISSN: 1352-0504; 1365-2893
• DOI: 10.1111/jvh.12638

Summary Long‐term prognosis varies widely among patients with hepatitis B virus (HBV)‐related liver cirrhosis. Our study aimed to investigate the applicability of albumin‐bilirubin (ALBI), Child‐Pugh and model for end‐stage liver disease (MELD) scores to the long‐term prognosis prediction of HBV‐related cirrhosis. Patients diagnosed with HBV‐associated cirrhosis from the First Affiliated Hospital of Wenzhou Medical University between January 2010 and December 2015 were enrolled in this study. The patients were followed up every 3 months. The prognostic performance of ALBI in long‐term outcome prediction for HBV‐related cirrhosis was compared with Child‐Pugh and MELD scores using time‐dependent receiver operating characteristic curve (tdROC) and decision curve analysis. A total of 806 patients were included in our study with 275 (34.1%) deceased during the follow‐up. Multivariate Cox regression analysis showed that ALBI grade was an independent predictor associated with mortality. The tdROC analysis showed that ALBI score (0.787, 0.830 and 0.833) was superior to MELD (0.693, P=.003; 0.717, P