Treatment and survival outcomes of small cell carcinoma of the esophagus: an analysis of the National Cancer Data Base

SUMMARY Given the paucity of esophageal small cell carcinoma (SCC) cases, there are few large studies evaluating this disease. In this study, the National Cancer Data Base (NCDB) was utilized to analyze the clinical features, treatment, and survival of patients with esophageal SCC in a large, popula...

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Bibliographic Details
Published in:Diseases of the esophagus 2017-02, Vol.30 (2), p.1-5
Main Authors: Wong, Andrew T., Shao, Meng, Rineer, Justin, Osborn, Virginia, Schwartz, David, Schreiber, David
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Antineoplastic Agents - therapeutic use
Antineoplastic Protocols
Carcinoma, Small Cell - mortality
Carcinoma, Small Cell - pathology
Carcinoma, Small Cell - therapy
Chemoradiotherapy - mortality
Combined Modality Therapy - methods
Databases, Factual
Esophageal Neoplasms - mortality
Esophageal Neoplasms - pathology
Esophageal Neoplasms - therapy
Esophagectomy - mortality
Female
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Multivariate Analysis
Neoplasm Staging
Proportional Hazards Models
Regression Analysis
Treatment Outcome
United States
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Summary:SUMMARY Given the paucity of esophageal small cell carcinoma (SCC) cases, there are few large studies evaluating this disease. In this study, the National Cancer Data Base (NCDB) was utilized to analyze the clinical features, treatment, and survival of patients with esophageal SCC in a large, population-based dataset. We selected patients diagnosed with esophageal SCC from 1998 to 2011. Patients were identified as having no treatment, chemotherapy alone, radiation ± sequential chemotherapy, concurrent chemoradiation, and esophagectomy ± chemotherapy and/or radiation. Overall survival (OS) was analyzed using the Kaplan–Meier method and compared using the log-rank test. Multivariate Cox regression analysis was conducted to identify factors associated with OS. A total of 583 patients were identified. Most patients had stage IV disease (41.7%). Regarding treatment selection, chemoradiation was the most commonly utilized for patients with nonmetasatic disease, whereas chemotherapy alone was most common for metastatic patients. Esophagectomy (median survival 44.9 months with 3 year OS 50.5%) was associated with the best OS for patients with localized (node-negative) disease compared with chemotherapy alone (p 
ISSN:1120-8694
1442-2050
DOI:10.1111/dote.12487