Radiation‐induced leukemia risk among those aged 0–20 at the time of the Chernobyl accident: A case‐control study in the Ukraine

A case‐control study was conducted to estimate the radiation‐induced acute leukemia risk for the period 1987–1997 among residents aged 0–20 at the time of the Chernobyl accident in the most radioactively contaminated territories of the Ukraine (Rivno and Zhytomir regions). Data were collected on 272...

Full description

Saved in:
Bibliographic Details
Published in:International journal of cancer 2002-06, Vol.99 (4), p.609-618
Main Authors: Noshchenko, Andriy G., Zamostyan, Pavlo V., Bondar, Oleksandra Yu, Drozdova, Vira D.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
Case-Control Studies
case‐control study
Chernobyl
Child
Child, Preschool
Female
Hematologic and hematopoietic diseases
Humans
Infant
Infant, Newborn
leukemia
Leukemia - epidemiology
Leukemia - etiology
Leukemia, Myeloid, Acute - epidemiology
Leukemia, Myeloid, Acute - etiology
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Male
Medical sciences
Neoplasms, Radiation-Induced - epidemiology
Neoplasms, Radiation-Induced - etiology
Power Plants
Precursor Cell Lymphoblastic Leukemia-Lymphoma - epidemiology
Precursor Cell Lymphoblastic Leukemia-Lymphoma - etiology
radiation
Radioactive Hazard Release
Risk Factors
Time Factors
Ukraine
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A case‐control study was conducted to estimate the radiation‐induced acute leukemia risk for the period 1987–1997 among residents aged 0–20 at the time of the Chernobyl accident in the most radioactively contaminated territories of the Ukraine (Rivno and Zhytomir regions). Data were collected on 272 leukemia cases diagnosed between 1 January 1987 and 31 December 1997. Of these, 98 cases were verified and interviewed. Verified cases were compared to 151 randomly selected controls matched by age, gender and type of settlement. The mean value of the estimated accumulated equivalent dose to the bone marrow was 4.5 mSv, and the maximum value was 101 mSv. A statistically significant increased risk of leukemia was found among males whose estimated radiation exposure was higher than 10 mSv. This association was statistically significant for acute leukemia cases that occurred in the period 1993–1997, particularly for acute lymphoblastic leukemia. A similar association was found for acute myeloid leukemia, diagnosed in the period 1987–1992. © 2002 Wiley‐Liss, Inc.
ISSN:0020-7136
1097-0215
DOI:10.1002/ijc.10406