Heteroleptic complexes of antifungal drugs with the silver ion

In spite of a large number of antibiotics and chemotherapeutics available for medical use, the emergence of old and new antibiotic resistance in the last decades revealed a substantial medical need for new classes of antimicrobial agents. In this paper we report the synthesis, characterization by el...

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Bibliographic Details
Published in:Journal of physical organic chemistry 2016-11, Vol.29 (11), p.656-664
Main Authors: Giulidori, Cecilia, Mosconi, Natalia, Toplikar, Brenda, Vega, Marisa, Williams, Patricia, Svetaz, Laura, Raimondi, Marcela, Rizzotto, Marcela
Format: Article
Language:English
Subjects:
albendazole
antifungal properties
Candida albicans
Candida tropicalis
heteroleptic complexes
silver complexes
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Summary:In spite of a large number of antibiotics and chemotherapeutics available for medical use, the emergence of old and new antibiotic resistance in the last decades revealed a substantial medical need for new classes of antimicrobial agents. In this paper we report the synthesis, characterization by elemental analysis, Fourier transform infrared and Nuclear magnetic resonance spectroscopies, and antifungal properties of two heteroleptic complexes of albendazole (albz) with Ag(I), using KSCN and o‐phenanthroline (phen) as the second ligand, respectively. Both complexes showed a moderate antifungal activity with all the assayed fungi, mainly Candida albicans and Candida tropicalis, that showed no activity against albendazole. Copyright © 2016 John Wiley & Sons, Ltd. In this paper we report the synthesis, characterization by elemental analysis, Fourier transform infrared and Nuclear magnetic resonance spectroscopies and antifungal properties of two heteroleptic complexes of albendazole (in the figure) with Ag(I), using KSCN and o‐phenanthroline as the second ligand, respectively. Both complexes showed a good or moderate antifungal activity with all the assayed fungi, mainly Candida albicans and Candida tropicalis, that showed no activity against albendazole.
ISSN:0894-3230
1099-1395
DOI:10.1002/poc.3603