Predictors of improved survival for patients with retroperitoneal sarcoma

Background Retroperitoneal sarcomas are rare tumors that can be locally aggressive with high rates of recurrence. Given that data on survival in patients with retroperitoneal sarcomas are conflicting, we sought to use a nationwide cancer database to identify factors associated with survival in patie...

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Bibliographic Details
Published in:Surgery 2016-12, Vol.160 (6), p.1628-1635
Main Authors: Giuliano, Katherine, MD, Nagarajan, Neeraja, MD, MPH, Canner, Joseph K., MHS, Wolfgang, Christopher L., MD, MS, PhD, Bivalacqua, Trinity, MD, PhD, Terezakis, Stephanie, MD, Herman, Joseph, MD, Schneider, Eric B., PhD, Ahuja, Nita, MD
Format: Article
Language:English
Subjects:
Aged
Combined Modality Therapy
Female
Humans
Male
Middle Aged
Neoplasm Grading
Neoplasm Staging
Retroperitoneal Neoplasms - mortality
Retroperitoneal Neoplasms - pathology
Retroperitoneal Neoplasms - therapy
Retrospective Studies
Sarcoma - mortality
Sarcoma - pathology
Sarcoma - therapy
SEER Program
Surgery
Survival Analysis
Survival Rate
United States - epidemiology
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Summary:Background Retroperitoneal sarcomas are rare tumors that can be locally aggressive with high rates of recurrence. Given that data on survival in patients with retroperitoneal sarcomas are conflicting, we sought to use a nationwide cancer database to identify factors associated with survival in patients with retroperitoneal sarcomas. Methods The Surveillance, Epidemiology, and End Results database was utilized to identify patients with retroperitoneal sarcomas from 2002 to 2012. Univariable and multivariable survival analysis was performed using a generalized gamma parametric survival function. Results A total of 2,920 patients were included; overall 5- and 10-year survivals were 58.4% and 45.3%, respectively. On multivariable survival analysis, age, histologic type, grade, size, local extension, lymph node, and distant metastasis were associated with decreased survival (all P  
ISSN:0039-6060
1532-7361
DOI:10.1016/j.surg.2016.05.041