In vitro anticancer activity of silver nanoparticle synthesized by Escherichia coli VM1 isolated from marine sediments of Ennore southeast coast of India

•The observed lattice fringes display indicates that the nanoparticles were good crystals.•This is conceivably the first report on the anticancer activity of Ag NPs synthesized by marine E. coli VM1.•The observed results indubitably supports that Ag NPs synthesized by marine E. coli give new hope as...

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Bibliographic Details
Published in:Enzyme and microbial technology 2016-12, Vol.95, p.146-154
Main Authors: Maharani, Viswanathan, Sundaramanickam, Arumugam, Balasubramanian, Thangavel
Format: Article
Language:English
Subjects:
A549 Cells
Animals
Anticancer activity
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Biosynthesis
Cercopithecus aethiops
Drug Screening Assays, Antitumor
Escherichia coli
Escherichia coli - classification
Escherichia coli - isolation & purification
Escherichia coli - metabolism
Geologic Sediments - microbiology
Green Chemistry Technology
HeLa Cells
Humans
In Vitro Techniques
India
Metal Nanoparticles - chemistry
Metal Nanoparticles - ultrastructure
Silver - chemistry
Silver - pharmacology
Silver nanoparticle
Spectroscopy, Fourier Transform Infrared
Vero Cells
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Summary:•The observed lattice fringes display indicates that the nanoparticles were good crystals.•This is conceivably the first report on the anticancer activity of Ag NPs synthesized by marine E. coli VM1.•The observed results indubitably supports that Ag NPs synthesized by marine E. coli give new hope as anticancer agents. In the present investigation, the bacterium Escherichia coli (VM1) was isolated from a marine sediments of Ennore coastal water along southeast coast of India was exploited for its capability of Ag NPs synthesis. The derived nanoparticles were characterized employing ultraviolet–visible (UV–vis) spectroscopy, Fourier Transform Infrared (FTIR) spectroscopy, X-ray diffraction and High Resolution Transmission Electron Microscopy (HRTEM) studies. The Ag NPs were further subjected to MTT assay to evaluate their anticancer activity against human lung cancer cell line (A549), human cervical cancer cell line (HeLa) and normal (Vero) cell line. The marine E. coli (VM1) synthesized silver nanoparticles exhibited considerable cytotoxic influence against human cancer cell lines, thereby suggesting that they have tremendous potential as effective anticancer agents.
ISSN:0141-0229
1879-0909
DOI:10.1016/j.enzmictec.2016.09.008