High‐intensity focused ultrasound treatment for skin: ex vivo evaluation

Background/Purpose High‐intensity focused ultrasound (HIFU) has been used for skin tightening. However, there is a rising concern of irreversible adverse effects. Our aim was to evaluate the depth of thermal injury zone after HIFU energy passes through different condition. Materials and Methods To a...

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Bibliographic Details
Published in:Skin research and technology 2017-08, Vol.23 (3), p.384-391
Main Authors: Park, J.‐H., Lim, S.‐D., Oh, S. H., Lee, J. H., Yeo, U. C.
Format: Article
Language:English
Subjects:
Animals
Biomimetics - methods
Burns - etiology
Coagulation
Energy
Epidermis
ex vivo experiment
Fascia
Fluence
High-Intensity Focused Ultrasound Ablation - adverse effects
High-Intensity Focused Ultrasound Ablation - instrumentation
high‐intensity focused ultrasound
Muscles - anatomy & histology
Muscles - pathology
porcine skin
Side effects
Skin
Skin - anatomy & histology
Skin - pathology
skin condition
Skin Diseases - etiology
Skin Diseases - pathology
Subcutaneous Fat - cytology
Subcutaneous Fat - pathology
Swine
Thermal injury
Tightening
Tissues
treatment parameter
Ultrasonic imaging
Ultrasound
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Summary:Background/Purpose High‐intensity focused ultrasound (HIFU) has been used for skin tightening. However, there is a rising concern of irreversible adverse effects. Our aim was to evaluate the depth of thermal injury zone after HIFU energy passes through different condition. Materials and Methods To analyze the consistency of the HIFU device, phantom tests were performed. Simulations were performed on ex vivo porcine tissues to estimate the area of the thermal coagulation point (TCP) according to the applied energy and skin condition. The experiment was designed in three orientations: normal direction (from epidermis to fascia), reverse direction (from fascia to epidermis), and normal direction without epidermis. Results The TCP was larger and wider depending on the applied fluence and handpieces (HPs). When we measured TCP in different directions, the measured area in the normal direction was more superficially located than that in the reverse direction. The depth of the TCP in the porcine skin without epidermis was detected at 130% deeper than in skin with an intact epidermis. Conclusion The affected area by HIFU is dependent on the skin condition and the characteristics of the HP and applied fluence. Considerations of these factors may be the key to minimize the unwanted adverse effects.
ISSN:0909-752X
1600-0846
DOI:10.1111/srt.12347