Villus packing density and lacunarity: Markers of placental efficiency?

Abstract We evaluate, in routine H&E histology slides, villus quantity in a given area (villous packing density, VPD) and the pattern or "gappiness" of villous distribution (lacunarity), and test for correlations with a proxy for fetoplacental metabolic rate, β calculated as (ln (place...

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Bibliographic Details
Published in:Placenta (Eastbourne) 2016-12, Vol.48, p.68-71
Main Authors: Shah, R.G, Salafia, C.M, Girardi, T, Merz, G.S
Format: Article
Language:English
Subjects:
Chorionic Villi - anatomy & histology
Chorionic Villi - physiology
Female
Humans
Image segmentation
Internal Medicine
Lacunarity
Obstetrics and Gynecology
Oxygen Consumption - physiology
Placenta
Placenta - anatomy & histology
Placenta - physiology
Placental efficiency
Pregnancy
Villus packing density
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Summary:Abstract We evaluate, in routine H&E histology slides, villus quantity in a given area (villous packing density, VPD) and the pattern or "gappiness" of villous distribution (lacunarity), and test for correlations with a proxy for fetoplacental metabolic rate, β calculated as (ln (placental weight)/ln (birthweight)) from Kleiber's law [1]. Three ∼4.3 mm2 images each were obtained from 88 term placentas. Ranges of VPD and lacunarity were each correlated with β (r = 0.31, p = 0.003, r = 0.23, p = 0.03 and respectively). The relationship between β and within-placenta variation in VPD and lacunarity highlights the need to study not merely the mean but the variance of villous geometries and spatial distributions.
ISSN:0143-4004
1532-3102
DOI:10.1016/j.placenta.2016.09.018