Copeptin – A potential endocrine surrogate marker of CCK-4-induced panic symptoms?

Highlights • Copeptin is a surrogate marker for pro-arginine-vasopressin. • We investigated copeptin secretion during CCK-4 panic provocation. • Copeptin correlated positively with panic symptoms. • Copeptin correlated also positively with ACTH and cortisol. • Findings suggest a role of copeptin as...

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Bibliographic Details
Published in:Psychoneuroendocrinology 2017-02, Vol.76, p.14-18
Main Authors: Demiralay, Cüneyt, Agorastos, Agorastos, Yassouridis, Alexander, Jahn, Holger, Wiedemann, Klaus, Kellner, Michael
Format: Article
Language:English
Subjects:
Adrenocorticotropic Hormone - blood
Adult
Anxiety - chemically induced
Biomarkers - blood
CCK-4
Cholecystokinin
Copeptin
Endocrinology & Metabolism
Glycopeptides - blood
HPA-axis
Humans
Hydrocortisone - blood
Male
Neurotransmitter Agents - pharmacology
Panic
Panic - physiology
Psychiatry
Receptors, Cholecystokinin - agonists
Surrogate marker
Tetragastrin - pharmacology
Young Adult
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Summary:Highlights • Copeptin is a surrogate marker for pro-arginine-vasopressin. • We investigated copeptin secretion during CCK-4 panic provocation. • Copeptin correlated positively with panic symptoms. • Copeptin correlated also positively with ACTH and cortisol. • Findings suggest a role of copeptin as potential surrogate marker of CCK-4 panic symptoms.
ISSN:0306-4530
1873-3360
DOI:10.1016/j.psyneuen.2016.11.006