Cardiac troponin I release after severe scorpion envenoming by Tityus serrulatus

Eight children aged 2–9 years, with signs and symptoms of severe scorpion envenoming by Tityus serrulatus were studied. All patients showed clinical manifestations of cardiac dysfunction, with ECG and echocardiographic alteration and five developed pulmonary edema. Troponin I levels were normal in a...

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Bibliographic Details
Published in:Toxicon (Oxford) 2002-06, Vol.40 (6), p.823-830
Main Authors: Cupo, Palmira, Hering, Sylvia Evelyn
Format: Article
Language:English
Subjects:
Animal poisons toxicology. Antivenoms
Animals
Antivenins - therapeutic use
Biological and medical sciences
Cardiac troponin I
Cardiomyopathies - blood
Cardiomyopathies - etiology
Cardiomyopathies - physiopathology
Child
Child, Preschool
Drug Therapy, Combination
Echocardiography
Female
Glucocorticoids - therapeutic use
Histamine H1 Antagonists - therapeutic use
Histamine H2 Antagonists - therapeutic use
Humans
Male
Medical sciences
Myocardial damage
Pulmonary Edema - blood
Pulmonary Edema - etiology
Pulmonary Edema - physiopathology
Scorpion envenoming
Scorpion Stings - blood
Scorpion Stings - complications
Scorpion Stings - physiopathology
Scorpions
Tityus serrulatus
Toxicology
Troponin I - blood
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Summary:Eight children aged 2–9 years, with signs and symptoms of severe scorpion envenoming by Tityus serrulatus were studied. All patients showed clinical manifestations of cardiac dysfunction, with ECG and echocardiographic alteration and five developed pulmonary edema. Troponin I levels were normal in all patients on admission, except for two who arrived later, and increased thereafter, with maximum values being observed 24–36 h after the sting. The detection of TnI in patients with severe scorpion envenoming, and the observed temporal pattern and serum levels meet the criteria established for the diagnosis of acute myocardial infarction. The rapid reversibility of cardiac dysfunction, together with the normalization of the enzymatic, ECG and echocardiographic data, indicates the occurrence of an acute myocardial lesion without underlying or associated coronary disease.
ISSN:0041-0101
1879-3150
DOI:10.1016/S0041-0101(02)00080-6