Physical, Chemical, and Biological Properties of S-Allylcysteine, an Amino Acid Derived from Garlic

Physical, chemical, and biological properties of S-allylcysteine (SAC) were investigated. SAC showed stable properties under tested conditions, and its acute/subacute toxicity was very minor in mice and rats (LD50 value >54.7 mM/kg po; >20 mM/kg ip). The pharmacokinetics of SAC was investigate...

Full description

Saved in:
Bibliographic Details
Published in:Journal of agricultural and food chemistry 2002-01, Vol.50 (3), p.622-632
Main Authors: Kodera, Yukihiro, Suzuki, Ayumi, Imada, Osamu, Kasuga, Shigeo, Sumioka, Isao, Kanezawa, Atsushi, Taru, Nobuo, Fujikawa, Masanori, Nagae, Shinji, Masamoto, Koji, Maeshige, Katsuhiko, Ono, Kazuhisa
Format: Article
Language:English
Subjects:
Administration, Oral
Animals
Biological and medical sciences
Cysteine - analogs & derivatives
Cysteine - chemistry
Cysteine - pharmacokinetics
Cysteine - toxicity
Female
Garlic - chemistry
Garlic - metabolism
General pharmacology
Humans
Intestinal Absorption
Lethal Dose 50
Male
Medical sciences
Mice
Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions
Pharmacology. Drug treatments
Rats
Rats, Wistar
Toxicity Tests
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Physical, chemical, and biological properties of S-allylcysteine (SAC) were investigated. SAC showed stable properties under tested conditions, and its acute/subacute toxicity was very minor in mice and rats (LD50 value >54.7 mM/kg po; >20 mM/kg ip). The pharmacokinetics of SAC was investigated after oral administration of garlic supplement containing SAC to human volunteers. SAC from garlic consumption was rapidly absorbed from the gastrointestinal tract, however, the half-life and excretion time were more than 10 h and 30 h, respectively. Keywords: Garlic; S-allylcysteine; toxicity; stability; pharmacokinetics
ISSN:0021-8561
1520-5118
DOI:10.1021/jf0106648