Antimicrobial silver-filled silica nanorattles with low immunotoxicity in dendritic cells

Abstract The progression in the use of orthopedic implants has led to an increase in the absolute number of implant infections, triggering a search for more effective antibacterial coatings. Nanorattles have recently gained interest in biomedical applications such as drug delivery, as encapsulation...

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Bibliographic Details
Published in:Nanomedicine 2017-01, Vol.13 (1), p.11-22
Main Authors: Priebe, Magdalena, Widmer, Jérôme, Löwa, Nina Suhartha, Abram, Sarah-Luise, Mottas, Inès, Woischnig, Anne-Kathrin, Brunetto, Priscilla S, Khanna, Nina, Bourquin, Carole, Fromm, Katharina M
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - pharmacology
Antimicrobial properties
Cells, Cultured
Dendritic cells
Dendritic Cells - drug effects
Dendritic Cells - metabolism
Escherichia coli - drug effects
Immunoresponse
Internal Medicine
Metal Nanoparticles - chemistry
Mice
Microbial Sensitivity Tests
Nanorattles
Phagocytosis
Silica nanocontainers
Silicon Dioxide - chemistry
Silver - pharmacology
Silver nanoparticles
Staphylococcus aureus - drug effects
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Summary:Abstract The progression in the use of orthopedic implants has led to an increase in the absolute number of implant infections, triggering a search for more effective antibacterial coatings. Nanorattles have recently gained interest in biomedical applications such as drug delivery, as encapsulation of the cargo inside the hollow structure provides a physical protection from the surrounding environment. Here, silver-containing silica nanorattles (Ag@SiO2 ) were evaluated for their antimicrobial potential and for their impact on cells of the immune system. We show that Ag@SiO2 nanorattles exhibited a clear antibacterial effect against Escherichia coli as well as Staphylococcus aureus found in post-operative infections. Immunotoxicological analyses showed that the particles were taken up through an active phagocytic process by dendritic cells of the immune system and did not affect their viability nor induce unwanted immunological effects. Silver-containing silica nanorattles thus fulfill several prerequisites for an antibacterial coating on surgical implants.
ISSN:1549-9634
1549-9642
DOI:10.1016/j.nano.2016.08.002