Antitumor Effects of Sorbus aucuparia L. Extract Highly Saturated with Anthocyans and Their Mechanisms

The effects of Fructus Sorbi aucupariae extract, originally saturated with anthocyans, on the development of Lewis lung carcinoma and B-16 melanoma in C57Bl/6 mice and the efficiency of cyclophosphamide treatment were studied. Antitumor activity of the extract and potentiation of the antimetastatic...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2016-11, Vol.162 (1), p.93-97
Main Authors: Razina, T. G., Zueva, E. P., Ulrich, A. V., Rybalkina, O. Yu, Chaikovskii, A. V., Isaikina, N. V., Kalinkina, G. I., Zhdanov, V. V., Zyuz’kov, G. N.
Format: Article
Language:English
Subjects:
Analysis
Animals
Anthocyanins - pharmacology
Antineoplastic Agents, Alkylating - pharmacology
Antineoplastic Agents, Phytogenic - isolation & purification
Antineoplastic Agents, Phytogenic - pharmacology
Antitumor activity
Biomedical and Life Sciences
Biomedicine
Carcinoma, Lewis Lung - drug therapy
Carcinoma, Lewis Lung - pathology
Cell Biology
Cyclophosphamide
Cyclophosphamide - pharmacology
Development and progression
Drug Synergism
Drug Therapy, Combination
Female
Fruit - chemistry
Injections, Intramuscular
Internal Medicine
Laboratory Medicine
Lung cancer
Lung carcinoma
Lymphatic Metastasis
Melanoma
Melanoma, Experimental - drug therapy
Melanoma, Experimental - pathology
Mice
Mice, Inbred C57BL
Neoplasm Transplantation
Neoplastic Stem Cells - drug effects
Neoplastic Stem Cells - pathology
Pathology
Plant Extracts - isolation & purification
Plant Extracts - pharmacology
Sorbus - chemistry
Stem cells
Tumor Burden - drug effects
Tumor Cells, Cultured
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Summary:The effects of Fructus Sorbi aucupariae extract, originally saturated with anthocyans, on the development of Lewis lung carcinoma and B-16 melanoma in C57Bl/6 mice and the efficiency of cyclophosphamide treatment were studied. Antitumor activity of the extract and potentiation of the antimetastatic activity of the cytostatic were demonstrated. Studies on melanoma B-16 model revealed an increase in the counts of stromal progenitor cells in the tumor node and their accelerated maturation after treatment with the extract. No effects towards the tumor stem and committed cells were detected.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-016-3554-4