Effects of carbendazim on rat thyroid, parathyroid, pituitary and adrenal glands and their hormones

The purpose of this study is to determine the effects of low and high dose of carbendazim on the level of certain hormones and endocrine glands (thyroid, parathyroid, adrenal and pituitary glands) of male rats. Carbendazim is a systemic fungicide with activity against a number of plant pathogens. In...

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Bibliographic Details
Published in:Human & experimental toxicology 2002-04, Vol.21 (4), p.217-221
Main Authors: Barlas, N, Selmanoglu, G, Kockaya, A, Songür, S
Format: Article
Language:English
Subjects:
Adrenal glands
Adrenal Glands - drug effects
Adrenal Glands - pathology
Adrenocorticotropic Hormone - analysis
Air Pollutants - toxicity
Animals
Benzimidazoles - administration & dosage
Benzimidazoles - toxicity
Biological and medical sciences
Body Weight - drug effects
Carbamates
Fungicides
Growth Hormone - analysis
Growth hormones
Hormones - analysis
Male
Medical sciences
Organ Size - drug effects
Parathyroid Glands - drug effects
Parathyroid Glands - pathology
Pesticides, fertilizers and other agrochemicals toxicology
Pituitary Gland - drug effects
Radioimmunoassay
Rats
Sperm
Thyroid gland
Thyroid Gland - drug effects
Thyroid Gland - pathology
Thyrotropin - analysis
Thyroxine - analysis
Toxicology
Triiodothyronine - analysis
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Summary:The purpose of this study is to determine the effects of low and high dose of carbendazim on the level of certain hormones and endocrine glands (thyroid, parathyroid, adrenal and pituitary glands) of male rats. Carbendazim is a systemic fungicide with activity against a number of plant pathogens. In this study, daily doses of 0, 150, 300 and 600 mg/kg per day carbendazim were applied to male rats by gavage for 15 weeks. At the end of the experiment, T3, T4, TSH, ACTH and GH levels in rat serum were analysed. Thyroid, parathyroid, adrenal and pituitary glands of rats were taken. A significant increase was observed in serum T3 levels of the rats, which were exposed to 300 mg/kg per day carbendazim doses, compared to the serum T3 levels of the control group. There were no differences between the control and carbendazim-treated group of rats regarding serum TSH, T4, ACTH and growth hormone levels. This showed us that carbendazim caused histopathological damages in thyroid, parathyroid and adrenal glands of rats. No changes were observed in pituitary glands of treated rats. These results suggest that a high quantity of subchronic carbendazim exposure affects thyroid, parathyroid and adrenal glands.
ISSN:0960-3271
1477-0903
DOI:10.1191/0960327102ht187oa