Serum metalloproteinase 9 levels increase after generalized tonic-clonic seizures

Highlights • We investigated changes in MMP9 serum levels after acute seizures in epilepsy patients. • Concentrations of MMP9 in serum were measured by ELISA in 43 patients 1–3, 24, and 72 h after generalized tonic-clonic seizure and once in participants of the control group. • MMP9 levels were sign...

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Bibliographic Details
Published in:Epilepsy research 2017-01, Vol.129, p.33-36
Main Authors: Cudna, Agnieszka, Jopowicz, Anna, Mierzejewski, Paweł, Kurkowska-Jastrzębska, Iwona
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Analysis of Variance
Biomarkers - blood
Blood–brain barrier
Enzyme-Linked Immunosorbent Assay
Epilepsy
Epilepsy, Tonic-Clonic - blood
Epilepsy, Tonic-Clonic - enzymology
Female
Generalized tonic-clonic seizures
Humans
Male
Matrix Metalloproteinase 9 - blood
Metalloproteinase 9
Middle Aged
Neuroinflammation
Neurology
Time Factors
Young Adult
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Summary:Highlights • We investigated changes in MMP9 serum levels after acute seizures in epilepsy patients. • Concentrations of MMP9 in serum were measured by ELISA in 43 patients 1–3, 24, and 72 h after generalized tonic-clonic seizure and once in participants of the control group. • MMP9 levels were significantly increased 1–3 and 24 h after seizure and decreased to control levels 72 h after seizure. • Our results suggest that MMP9 is released after or just before seizure.
ISSN:0920-1211
1872-6844
DOI:10.1016/j.eplepsyres.2016.11.006