Sarcoidosis: Rheumatology perspective

Abstract Sarcoidosis is a systemic inflammatory granulomatous disease for which rheumatologists are uniquely trained and qualified to treat. Historically, sarcoidosis has been managed within silos of medical subspecialties, but with increased appreciation of the systemic nature of this disorder and...

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Bibliographic Details
Published in:Best practice & research. Clinical rheumatology 2016-04, Vol.30 (2), p.334-356
Main Author: Yee, Arthur M.F., MD PhD
Format: Article
Language:English
Subjects:
Humans
Rheumatology
Sarcoidosis
Sarcoidosis - diagnosis
Sarcoidosis - immunology
Sarcoidosis - therapy
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Summary:Abstract Sarcoidosis is a systemic inflammatory granulomatous disease for which rheumatologists are uniquely trained and qualified to treat. Historically, sarcoidosis has been managed within silos of medical subspecialties, but with increased appreciation of the systemic nature of this disorder and the availability of more therapeutic options, it is clear that a multidisciplinary approach, with the rheumatologist as a key component, can offer more optimal care. This manuscript reviews clinically relevant immunology and pathophysiology, diagnostic issues, management decision-making, and therapeutics in the care of patients with sarcoidosis. Issues particularly relevant to rheumatologists are highlighted. These include aiding in establishing diagnosis; recognition of disease manifestations involving bone, joint, and muscle; management of calcium metabolism and metabolic bone disease; and formulation and implementation of anti-inflammatory and immunomodulatory therapies.
ISSN:1521-6942
1532-1770
DOI:10.1016/j.berh.2016.07.001