Visualisation studies and glomerular filtration in early diabetic rats

Abstract The purpose of this mini-review is to show that more modern multi-photon microscopy approaches allow quantitative glomerular filtration experiments. Modern science has now entered a transition period from light microscopy to multi-photon confocal microscopy. Since the late 20th century, mul...

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Bibliographic Details
Published in:Journal of biomechanics 2017-01, Vol.50, p.138-143
Main Author: Nakamoto, Hiroshi
Format: Article
Language:English
Subjects:
Animal models
Animals
Blood
Calcium
Confocal microscopy
Diabetes
Diabetes mellitus
Diabetes Mellitus, Experimental - diagnostic imaging
Diabetes Mellitus, Experimental - physiopathology
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Filtrate
Filtration
Flow velocity
Glomerular filtration
Glomerular Filtration Rate
Humans
Hyperfiltration
In-vivo
Inhibition
Kidney
Kidney - diagnostic imaging
Kidney - physiopathology
Leakage
Light
Light microscopy
Mice
Microcirculation
Microscopy
Microscopy, Fluorescence, Multiphoton
Multi-photon microscopy
Optical microscopy
Organs
Peptides
Photons
Physical Medicine and Rehabilitation
Physiology
Probes
Pumps
Rats
Recording
Renal function
Rodents
Visualisation
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Description
Summary:Abstract The purpose of this mini-review is to show that more modern multi-photon microscopy approaches allow quantitative glomerular filtration experiments. Modern science has now entered a transition period from light microscopy to multi-photon confocal microscopy. Since the late 20th century, multi-photon microscopy has been applied in the study of organ function. In keeping with observations made in renal physiology and other representative studies throughout this transition period, and in the context of advancing microscopy techniques, this review has been presented as a comment on the glomerular filtration barrier, with a focus on the early aetiopathogenesis of diabetes.
ISSN:0021-9290
1873-2380
DOI:10.1016/j.jbiomech.2016.11.034