Cutaneous Histiocytic Sarcoma with Regional Lymph Node Metastasis in a Netherland Dwarf Rabbit (Oryctolagus cuniculus)

A 10-year-old male Netherland dwarf rabbit (Oryctolagus cuniculus) was presented with a red nodular mass (1 cm in diameter) with ulceration and hair loss in the skin of the left upper lip. Cytological examination revealed atypical round cells. The mass was excised surgically. Histologically, the mas...

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Bibliographic Details
Published in:Journal of comparative pathology 2017-02, Vol.156 (2-3), p.169-172
Main Authors: Karim, M.R., Izawa, T., Pervin, M., Sasai, H., Kuwamura, M., Yamate, J.
Format: Article
Language:English
Subjects:
Animals
Biomarkers, Tumor - analysis
histiocytic sarcoma
Histiocytic Sarcoma - veterinary
Immunohistochemistry
lymph node metastasis
Lymphatic Metastasis - pathology
Male
rabbit
Rabbits
skin
Skin Neoplasms - veterinary
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Summary:A 10-year-old male Netherland dwarf rabbit (Oryctolagus cuniculus) was presented with a red nodular mass (1 cm in diameter) with ulceration and hair loss in the skin of the left upper lip. Cytological examination revealed atypical round cells. The mass was excised surgically. Histologically, the mass was composed of large round to polyhedral neoplastic cells with marked cytological atypia. The neoplastic cells were often binucleated or multinucleated. Immunohistochemically, the neoplastic cells were intensely positive for Iba1 and vimentin, but fewer neoplastic cells expressed E-cadherin. Nuclear immunoreactivity for Ki67 was detected in approximately 41% of the neoplastic cells. Metastasis to the left cervical lymph nodes was detected 6 months after the surgical excision. Based on clinical, histopathological and immunohistochemical findings, the present case was diagnosed as cutaneous histiocytic sarcoma. To the authors' knowledge cutaneous histiocytic disease has not been reported previously in lagomorphs.
ISSN:0021-9975
1532-3129
DOI:10.1016/j.jcpa.2016.10.009