Mathematical Models for Controlled Drug Release Through pH-Responsive Polymeric Hydrogels

Hydrogels consisting of weakly charged acidic/basic groups are ideal candidates for carriers in oral delivery, as they swell in response to pH changes in the gastrointestinal tract, resulting in drug entrapment at low pH conditions of the stomach and drug release at high pH conditions of the intesti...

Full description

Saved in:
Bibliographic Details
Published in:Journal of pharmaceutical sciences 2017-02, Vol.106 (2), p.629-638
Main Authors: Manga, Ramya D., Jha, Prateek K.
Format: Article
Language:English
Subjects:
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacokinetics
controlled release
Delayed-Action Preparations - chemistry
diffusion
Drug Liberation
gastrointestinal
Gastrointestinal Tract - metabolism
Humans
hydrogels
Hydrogels - chemistry
Hydrogen-Ion Concentration
mathematical model
Micelles
Models, Biological
Models, Chemical
oral drug delivery
pharmacokinetics
polyelectrolytes
polymeric drug carrier
Polymers - chemistry
Taxoids - administration & dosage
Taxoids - chemistry
Taxoids - pharmacokinetics
thermodynamics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Hydrogels consisting of weakly charged acidic/basic groups are ideal candidates for carriers in oral delivery, as they swell in response to pH changes in the gastrointestinal tract, resulting in drug entrapment at low pH conditions of the stomach and drug release at high pH conditions of the intestine. We have developed 1-dimensional mathematical models to study the drug release behavior through pH-responsive hydrogels. Models are developed for 3 different cases that vary in the level of rigor, which together can be applied to predict both in vitro (drug release from carrier) and in vivo (drug concentration in the plasma) behavior of hydrogel-drug formulations. A detailed study of the effect of hydrogel and drug characteristics and physiological conditions is performed to gain a fundamental insight into the drug release behavior, which may be useful in the design of pH-responsive drug carriers. Finally, we describe a successful application of these models to predict both in vitro and in vivo behavior of docetaxel-loaded micelle in a pH-responsive hydrogel, as reported in a recent experimental study.
ISSN:0022-3549
1520-6017
DOI:10.1016/j.xphs.2016.10.019