Andrée Gruslin award lecture: Metabolomics as an important modality to better understand preeclampsia

Abstract Preeclampsia (PE) is a complex disorder that affects 3–5% of all pregnancies and is a leading cause of maternal and fetal morbidity and mortality. To date, the heterogeneity of clinical presentation, disease severity and outcomes have limited significant advances in early prediction, diagno...

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Bibliographic Details
Published in:Placenta (Eastbourne) 2017-12, Vol.60, p.S32-S40
Main Authors: Benton, S.J, Ly, C, Vukovic, S, Bainbridge, S.A
Format: Article
Language:English
Subjects:
Animals
Biomarkers
Biomarkers - metabolism
Biomedical Research - methods
Biomedical Research - trends
Female
Humans
Internal Medicine
Metabolites
Metabolomics
Metabolomics - methods
Metabolomics - trends
Models, Biological
Obstetrics and Gynecology
Pathophysiology
Placenta - metabolism
Placenta - physiopathology
Pre-Eclampsia - diagnosis
Pre-Eclampsia - metabolism
Pre-Eclampsia - physiopathology
Pre-Eclampsia - therapy
Precision Medicine
Preeclampsia
Pregnancy
Research Design - trends
Uterus - metabolism
Uterus - physiopathology
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Summary:Abstract Preeclampsia (PE) is a complex disorder that affects 3–5% of all pregnancies and is a leading cause of maternal and fetal morbidity and mortality. To date, the heterogeneity of clinical presentation, disease severity and outcomes have limited significant advances in early prediction, diagnosis, and therapeutic intervention of PE. The rapidly expanding field of metabolomics, which has the capacity to quantitatively detect low molecular weight compounds (metabolites) in tissue and biological fluids, shows tremendous promise in gaining a better understanding of PE. This review will discuss this emerging field and its contribution to recent advances in the understanding of PE pathophysiology, and identification of early predictive metabolic biomarkers for this complex disorder.
ISSN:0143-4004
1532-3102
1532-3102
DOI:10.1016/j.placenta.2016.11.006