Autologous bone marrow stem cell transplantation for the treatment of ulcerative colitis complicated with herpes zoster： a case report

Ulcerative colitis （UC） is a chronic inflammatory bowel disease with continuous or recurrent symptoms. A 42-year-old male patient with intermittent diarrhea accompanied by bloody mucopurulent stools was admitted to our hospital. The diagnosis of UC was confirmed by a combination of laboratory examin...

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Bibliographic Details
Published in:Frontiers of medicine 2016-12, Vol.10 (4), p.522-526
Main Authors: Xiang, Hang, Zhang, Xiaomei, Yang, Chao, Xu, Wenhuan, Ge, Xin, Zhang, Rong, Qiu, Ya, Sun, Wanjun, Li, Fan, Xiang, Tianyuan, Chen, Haixu, Wang, Zheng, Zeng, Qiang
Format: Article
Language:English
Subjects:
Adult
autograft
Bone marrow
Bone Marrow - pathology
bone marrow stem cells
Bone Marrow Transplantation
Case Report
Case reports
cell therapy
Clinical Trials as Topic
Colitis, Ulcerative - complications
Colitis, Ulcerative - pathology
Colitis, Ulcerative - therapy
Colon
Colonoscopy
Colorectal cancer
Herpes Zoster - complications
Humans
Inflammatory bowel disease
Intestinal Mucosa - cytology
Male
Medicine
Medicine & Public Health
Rectum - pathology
Remission Induction
Stem Cell Transplantation
Transplantation, Autologous
ulcerative colitis
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Summary:Ulcerative colitis （UC） is a chronic inflammatory bowel disease with continuous or recurrent symptoms. A 42-year-old male patient with intermittent diarrhea accompanied by bloody mucopurulent stools was admitted to our hospital. The diagnosis of UC was confirmed by a combination of laboratory examination, colonoscopy, and histological assay. The patient developed herpes zoster in the hospital, which challenged traditional treatments. Therefore, we performed an autologous bone marrow cells to modulate the immune system with his permission. Autologous bone marrow mononuclear cells were collected and injected locally into the bowel mucosa, and subsequently injected systemically through a peripheral vein. After the patient underwent auto bone marrow mononuclear cells transplantations twice, the patient＇s symptoms were alleviated. Furthermore, he recovered from bematochezia, and his hypersensitive C reactive protein decreased. Colonoscopy results showed reduced lesions and decreased areas with bleeding and edema in the sigmoid colon and rectum. No recurrence occurred in the subsequent two years, but long-time monitoring is still necessary for the prophylaxis of colorectal cancer.
ISSN:2095-0217
2095-0225
DOI:10.1007/s11684-016-0485-4